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Does a hypersensitive immune response to helminth infection at duodenum make Merino sheep susceptible to diarrhoea?

ABSTRACT: Does a hypersensitive immune response to helminth infection at duodenum make Merino sheep susceptible to diarrhoea?

PROVIDER: PRJNA736720 | ENA |

REPOSITORIES: ENA

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Does a hypersensitive immune response to helminth infection at duodenum make Merino sheep susceptible to diarrhoea?

Project description:Purpose:To explore the underlying biological mechanisms relating to development and control of diarrhoea, we compared sheep that were prone to develop diarrhoea with sheep that were not prone. Methods:Transcriptomes in the tissues of Merino sheep where the parasites were located were analyzed using RNASeq. Functional enrichment of DEGs using GO terms in biological processes and KEGG pathways were studied. PPI (protein-protein interaction) network and sub-network were studied using clusterONE plugin in Cytoscape. Result and conclusion: Our results indicate that suppression of ‘immune response’, ‘antigen processing and presentation’, and a list of biological functional terms related to ‘suppression in immune tolerance and activation of repair processes associated with tissue damage, including ‘extracellular matrix organization’, ‘collagen fibril organization’, ‘tissue morphogenesis’, ‘circulatory system development’, ‘morphogenesis of an epithelium’, and ‘focal adhesion’ were associated with high-diarrhoea phenotype. The genes with important roles in the responses to helminth infection could be targeted in breeding programs to prevent diarrhoea.

2022-06-10 | GSE176569 | GEO

Does an immune response at the Ileum contribute to severity and development of helminth-diarrhoea in Merino sheep (ileum)?

Project description:Purpose: To investigaet whether an inflammatory immune response at the Ileum can contribute to development and severity of diarrhoea in Merino sheep that are prone and not prone to develop diarrhoea. Methods:Transcriptomes in the Ileum (third part of small intestine) of Merino sheep were analyzed using RNASeq. Functional enrichment of DEGs using GO terms in biological processes and KEGG pathways were studied. PPI (protein-protein interaction) network and sub-network were studied using clusterONE plugin in Cytoscape. Result and conclusion: Although Ileum in not a primary site of helminth (species under study in our experiment), the results indicated that an inflammatory immune response can contribute to development and severity of diarrhoea. The low-diarrhoea animals did not show any signs of immune/inflammatory response. The genes with important roles in the responses to helminth infection could be targeted in breeding programs to prevent diarrhoea.

2022-06-27 | GSE179149 | GEO

Does an immune response at the Ileum contribute to severity and development of helminth-diarrhoea in Merino sheep (ileum)?

Project description:Does an immune response at the Ileum contribute to severity and development of helminth-diarrhoea in Merino sheep (ileum)?

| PRJNA742414 | ENA

Regulatory and epistatic networks unravel the complexity of piebald, a pigmentation phenotype in Merino sheep

Project description:Transcriptional profiling of Ovine skin samples comparing pigmentation samples from piebald and normal Merino sheep

2010-09-18 | GSE24189 | GEO

Effect of bovine viral diarrhoea virus infection in Madin-Darby bovine kidney cells

Project description:Analysis of gene expression induced in Madin-Darby bovine kidney cells (MDBK) infected with Bovine viral diarrhoea virus BVDV2 strain 1373. Keywords: other

2004-05-31 | GSE756 | GEO

Effect of bovine viral diarrhoea virus infection in Madin-Darby bovine kidney cells

Project description:Analysis of gene expression induced in Madin-Darby bovine kidney cells (MDBK) infected with Bovine viral diarrhoea virus BVDV2 strain 1373. Keywords: other

2004-05-31 | E-GEOD-756 | biostudies-arrayexpress

Ovis aries breed:Merino

Project description:Ovis aries breed:Merino Raw sequence reads

| PRJNA445172 | ENA

Ovis aries breed:Merino

Project description:Ovis aries breed:Merino Raw sequence reads

| PRJNA327701 | ENA

Regulatory and epistatic networks unravel the complexity of piebald, a pigmentation phenotype in Merino sheep

Project description:Transcriptional profiling of Ovine skin samples comparing pigmentation samples from piebald and normal Merino sheep All pair comparison of 5 pigmentation samples with dye swaps. Dye swaps were performed with different biological replicates (labelled 1 or 2) NOR - White sample from a normal, non-affected wild-type individual sheep PBB - Black sample from a piebald individual sheep PBW - White sample from a piebald individual sheep RSB - Black sample from a recessive black sheep RSW - White sample from a recissive black sheep taken from the inguinal, non-pigmented area.

2010-09-18 | E-GEOD-24189 | biostudies-arrayexpress

Comparative transcriptome profiling of longissimus muscle tissues from Qianhua Mutton Merino and Small Tail Han sheep

Project description:We aimed to evaluate the transcriptome regulators associated with muscle growth and development between the Qianhua Mutton Merino (QHMM) and Small Tail Han (STH) sheep.We used RNA-Seq to obtain the transcriptome profiles of the longissimus muscle from the QHMM and STH.The genome-wide transcriptome analysis of QHMM and STH muscle in present study is reported first time.

2017-02-14 | GSE84964 | GEO

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