Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome profiling of left ventricles from cardiac-specific miR-150 conditional knockout mice

ABSTRACT: Transcriptome profiling of left ventricles from cardiac-specific miR-150 conditional knockout mice

PROVIDER: PRJNA736985 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptome profiling of left ventricles from cardiac-specific miR-150 conditional knockout mice

Project description:Genome-wide transcriptomic analyses in left ventricles (LVs) from cardiac-specific miR-150 conditional knockout KO (cKO) mice were performed to identify novel miR-150 targets in the heart.

2021-08-18 | GSE177057 | GEO

Transcriptome profiling of left ventricles from cardiac-specific GRK-beta1AR transgenic and/or miR-150 transgenic mice treated with isoproterenol.

Project description:Genome-wide transcriptomic analyses in left ventricles (LVs) from cardiac-specific GRK-beta1AR transgenic (TG) and/or miR-150 TG mice treated with isoproterenol (ISO) were performed to identify novel targets of beta-arrestin-mediated beta1AR signaling and miR-150 in the heart.

2023-01-01 | GSE199195 | GEO

Circular RNA profiling of left ventricles from cardiac-specific GRK-beta1AR transgenic and/or miR-150 transgenic mice treated with isoproterenol.

Project description:Genome-wide circular RNA profiling analyses in left ventricles (LVs) from cardiac-specific GRK-beta1AR transgenic (TG) and/or miR-150 TG mice treated with isoproterenol (ISO) were performed to identify novel circular RNAs regulated by beta-arrestin-mediated beta1AR signaling and miR-150 in the heart.

2023-01-01 | GSE199290 | GEO

Effects of a Uty gene trap on the transcriptomic profile of mouse cardiac left ventricles in response to castration

Project description:Previous results from the laboratory showed that the genetic make up of chromosome Y modulated the effects of castration on the transcriptome of mouse cardiac left ventricles. To test the effect of the chromosome Y Uty locus, the current study tests how castration affects the transcriptomes of cardiac left ventricles from adult male carrying a Uty gene trap (KO) in comparison to wild-type (WT)couterparts.

2021-09-19 | GSE158370 | GEO

Left-right transcriptomic differences in adult male mouse heart ventricles

Project description:Left and right heart ventricles of adult male mice were profiled to determine the differences in gene expression, control, coordination and signaling fabrics Two-sides (L= left, R = right) gene expression profiling experiment in adult mouse male (M) ventricles (V). 4 biological replicates: MVL1-4, MVR1-4.

2013-03-21 | E-GEOD-45348 | biostudies-arrayexpress

Left-right transcriptomic differences in adult male mouse heart ventricles

Project description:Left and right heart ventricles of adult male mice were profiled to determine the differences in gene expression, control, coordination and signaling fabrics

2013-03-21 | GSE45348 | GEO

Transcriptome profiling of left ventricles from systemic MIAT knockout mice

Project description:Genome-wide transcriptomic analyses in left ventricles (LVs) from systemic MIAT knockout (KO) mice were performed to identify novel MIAT targets in the heart.

2022-01-10 | GSE185396 | GEO

Single cell RNA-seq comparison of cardiac fibroblasts from the left versus right ventricles

Project description:Cardiac fibrosis is a key aspect of heart failure, leading to reduced ventricular compliance and impaired electrical conduction in the myocardium. Various pathophysiologic conditions can lead to fibrosis in the left ventricle (LV) and/or right ventricle (RV). Despite growing evidence to support the transcriptomic heterogeneity of cardiac fibroblasts (CFs) in healthy and diseased states, there have been no direct comparisons of CFs in the LV and RV. Given the distinct natures of the ventricles, we hypothesized that LV and RV-derived CFs would display baseline transcriptomic differences that influence their proliferation and differentiation following injury. Bulk RNA sequencing of CFs isolated from healthy left and right cardiac ventricles indicated that left ventricle-derived CFs may be further along the myofibroblast transdifferentiation trajectory than cells isolated from the right ventricle. Single-cell RNA-sequencing (scRNA-seq) analysis of the two populations confirmed that Postn+ CFs are more enriched in the LV, whereas Igfbp3+ CFs were enriched in the RV at baseline. Notably, following pressure overload injury, the LV developed a larger subpopulation of pro-fibrotic Thbs4+/Cthrc1+ injury-induced CFs, while the RV showed unique expansion of two less-well characterized subpopulations of CFs (Igfbp3+ and Inmt+). These findings demonstrate that LV and RV-derived CFs display baseline subpopulation differences that may dictate their diverging responses to pressure overload injury. Further study of these subpopulations will elucidate their role in the development of fibrosis and inform whether LV and RV fibrosis require distinct treatments.

2024-02-28 | GSE254914 | GEO

RNA-seq of heart failure in human left ventricles

Project description:RNA-seq of heart failure in human left ventricles

| PRJNA477855 | ENA

Single cell RNA-seq comparison of cardiac fibroblasts from the left versus right ventricles [bulk RNA-seq]

2024-02-28 | GSE255542 | GEO