Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA methylation analysis of oropharyngeal squamous cell carcinoma

ABSTRACT: DNA methylation analysis of oropharyngeal squamous cell carcinoma

PROVIDER: PRJNA737789 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

DNA methylation analysis in oropharyngeal cancer [450K array]

Project description:DNA methylation analysis in oropharyngeal squamous carcinoma (OPSCC) samples and oropharyngeal non-cancerous mucosa samples. Infinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across 485,577 CpG sites. Total samples included 89 OPSCC samples and 5 non-cancerous mucosa samples.

2020-01-20 | GSE124464 | GEO

DNA methylation analysis in oropharyngeal cancer [EPIC array]

Project description:DNA methylation analysis in oropharyngeal squamous carcinoma (OPSCC) samples and oropharyngeal non-cancerous mucosa samples. Infinium MethylationEPIC BeadChip Kit was used to obtain DNA methylation profiles across more than 850,000 CpG sites. Total samples included 89 OPSCC samples and 5 non-cancerous mucosa samples.

2020-01-20 | GSE124632 | GEO

DNA methylation analysis of oropharyngeal squamous cell carcinoma

Project description:Upper aerodigestive tract (UADT) tumors present different biological behavior and prognosis, suggesting specific molecular mechanisms underlying their development. However, they are rarely considered as single entities (particularly head and neck subsites) and share the most common genetic alterations. Therefore, there is a need for a better understanding of the global DNA methylation differences among UADT tumors. We performed a genome-wide DNA methylation analysis of esophageal (ESCC), laryngeal (LSCC), oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas, and their non-tumor counterparts. The unsupervised analysis showed that non-tumor tissues present markedly distinct DNA methylation profiles, while tumors are highly heterogeneous. Hypomethylation was more frequent in LSCC and OPSCC, while ESCC and OSCC presented mostly hypermethylation, with the latter showing a CpG island overrepresentation. Differentially methylated regions affected genes in 127 signaling pathways, with only 3.1% of these being common among different tumor subsites, but with different genes affected. The WNT signaling pathway, known to be dysregulated in different epithelial tumors, is a frequent hit for DNA methylation and gene expression alterations in ESCC and OPSCC, but mostly for genetic alterations in LSCC and OSCC. UADT tumor subsites present differences in genome-wide methylation regarding their profile, intensity, genomic regions and signaling pathways affected.

2021-07-08 | GSE178219 | GEO

Epigenome analysis of oropharygeal squamous cell carcinoma

Project description:Genome wide DNA methylation profiling of normal and primary oropharyngeal squamous cell carcinoma tissue samples, some infected with the human papilloma virus (HPV). The Illumina Infinium 27k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 27,000 CpGs in tissue samples. Samples included 46 oropharyngeal SCC primary tumors and 46 normal adjacent mucosal samples. For each tumor sample, HPV status (positivity based on both DNA and E6/E7 RNA) and p16 immunohistochemistry status is included.

2014-06-07 | GSE58272 | GEO

Epigenome analysis of oropharygeal squamous cell carcinoma

2014-06-07 | E-GEOD-58272 | biostudies-arrayexpress

DNA methylation analysis of oral squamous cell carcinoma

Project description:DNA methylation analysis of oral squamous cell carcinoma

| PRJNA737785 | ENA

DNA methylation analysis of laryngeal squamous cell carcinoma

Project description:DNA methylation analysis of laryngeal squamous cell carcinoma

| PRJNA737790 | ENA

DNA methylation analysis of esophageal squamous cell carcinoma

Project description:DNA methylation analysis of esophageal squamous cell carcinoma

| PRJNA737784 | ENA

Next generation sequencing facilities quantitative analysis of human oropharyngeal squamous cell carcinoma, small cell carcinoma and non-cancerous tonsil tissue.

Project description:To investigate the differences of transcriptional activities between oropharyngeal squamous cell caricnoma and small cell carcinoma, we performed a transcriptomic analysis using high throoughput RNA sequencing (RNA-seq).

2021-02-16 | GSE166773 | GEO

DNA methylation analysis in oropharyngeal cancer

Project description:DNA methylation analysis in oropharyngeal cancer

| PRJNA512877 | ENA