Project description:Immune responses to cancer are highly variable, in particular colorectal cancer tumors with mismatch repair-deficiency (MMRd) show an elevated presence and activity of immune cells as compared to mismatch repair proficient tumors. To understand the immune response patterns, and key differences between these types of colorectal cancer, we transcriptionally profiled 371,223 tumor and adjacent normal cells from 28 MMRp and 34 MMRd patients. Unsupervised analysis identified 88 cell subsets, from 7 distinct cell lineages, and an associated compendium of 204 gene expression programs. Examination of these programs revealed extensive transcriptional and spatial reprogramming, characteristic to MMRd and MMRp tumors.

2021-08-26 | GSE178341 | GEO

Single cell transcriptomics of irradiated colorectal cancer organoids

Project description:Single cell RNA sequencing of two colorectal organoid lines that were irradiated plus their controls

2022-06-26 | E-MTAB-11849 | biostudies-arrayexpress

Single cell 3' RNA sequencing of 23 Korean colorectal cancer patients

Project description:For the understanding intrinsic cancer cell signatures and the surrounding microenviroment, we provide single-cell 3' RNA sequencing dataon 63,689 cells from 23 CRC patients with 23 primary colorectal cancer and 10 matched normal mucosa samples. Analysis of primary colorectal cancer and normal mucosa samples depicts a comprehensive cellular landscape of colorectal cancer and potential cellular interaction, which would be a valuable resource for the development of therapeutic strategies.

2020-04-04 | GSE132465 | GEO

Single-cell atlas of thalamic projection systems

Project description:Single-cell atlas of thalamic projection systems

| PRJNA552997 | ENA

A Single Cell Atlas of Alveolar Development

Project description:A Single Cell Atlas of Alveolar Development

| PRJNA693167 | ENA

University of Washington Developmental Single Cell Atlas

Project description:University of Washington Developmental Single Cell Atlas

| PRJNA622599 | ENA