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RNA sequence data from liver-specific Pten/Traf3 knockout mice

ABSTRACT: RNA sequence data from liver-specific Pten/Traf3 knockout mice

PROVIDER: PRJNA738931 | ENA |

REPOSITORIES: ENA

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RNA sequence data from liver-specific Pten/Traf3 knockout mice

Project description:Intrahepatic cholangiocarcinoma (ICC) is known to have a poor prognosis among primary liver cancers. We created a mouse model of cholangiocarcinogenesis by specifically deleting Pten and Traf3 in the liver. RNA sequence was performed with RNA extracted from the liver of mice lacking liver-specific Pten and Traf3.

2022-03-31 | GSE178418 | GEO

Single cell RNA sequence data from liver-specific Pten/Traf3 knockout mice

Project description:Intrahepatic cholangiocarcinoma (ICC) is known to have a poor prognosis among primary liver cancers. We created a mouse model of cholangiocarcinogenesis by specifically deleting Pten and Traf3 in the liver. single cell RNA sequence was performed with RNA extracted from the liver of mice lacking liver-specific Pten and Traf3.

2022-03-31 | GSE178814 | GEO

RNA sequence data from liver-specific Pten/Traf3 knockout mice [HepG2 RNA-seq]

Project description:Intrahepatic cholangiocarcinoma (ICC) is known to have a poor prognosis among primary liver cancers. We created a vitro model of cholangiocarcinogenesis using HepG2 with specifically knockdown of Pten and Traf3. RNA sequence was performed with RNA extracted from the liver of mice lacking liver-specific Pten and Traf3.

2022-03-31 | GSE184276 | GEO

Single cell RNA sequence data from liver-specific Pten/Traf3 knockout mice

Project description:Single cell RNA sequence data from liver-specific Pten/Traf3 knockout mice

| PRJNA741135 | ENA

RNA sequence data from liver-specific Pten/Traf3 knockout mice [HepG2 RNA-seq]

Project description:RNA sequence data from liver-specific Pten/Traf3 knockout mice [HepG2 RNA-seq]

| PRJNA763879 | ENA

Expression data of dorsolateral prostates from wild type, prostate-specific Pten knockout, and prostate-specific Pten and Pml double knockout mice

Project description:We used microarrays to analyze the global gene expression and to identify the differentially expressed genes among wild type, prostate-specific Pten knockout, and prostate-specific Pten and Pml double knockout prostates at 12 weeks of age.

2017-05-04 | GSE98493 | GEO

Hepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice

Project description:Gene expression of hepatocyt-specific knockout of Pten and of Pten and Tgfbr2 in mice as a model for human cholangiocarcinoma was determined Affymetrix Mouse 1.0ST chips were used to measure gene expression Gene expression of the following mouse livers were characterized A. WT (n=3). B. Pten-/- (n=4). C. Pten-/- Tgfbr2-/- (n=4).

2016-02-26 | E-GEOD-66717 | biostudies-arrayexpress

B lymphoma from TRAF3-deficient mice

Project description:Spleen samples with B lymphoma from TRAF3 knockout mice compared with littermate controls 3 lymphoma samples, 4 control samples

2014-09-11 | E-GEOD-48818 | biostudies-arrayexpress

Transcription profiling of mouse lymph node derived B cells from Traf2 and Traf3 B cell knockout mice and Baff tg mice

Project description:Tumor necrosis factor-associated factors 2 and 3 (TRAF2 and TRAF3) were shown to function in a co-operative and non-redundant manner to suppress nuclear factor-ÎºB2 (NF-ÎºB2) activation, gene expression and survival in mature B cells. In the absence of this suppressive activity, B cells developed independently of the obligatory B cell survival factor, BAFF (B cell activating factor of the tumor necrosis factor family). This constitutive, lineage-specific suppression of B cell survival by TRAF2 and TRAF3 determines the requirement for BAFF to sustain B cell development in vivo. We wished to investigate the effect on gene expression in B cells which lacked the negative regulators TRAF2 and TRAF3, and hence had hyperactive NF-kB2 signalling. As Baff-tg mice display a similar phenotype, and have a genetic modification which acts in the same pathway, yet further up, than TRAF2 and TRAF3, we wished to compare and contrast Baff-tg B cells with TRAF2 and TRAF3 deficient B cells. This analysis should identify genes that are important in B cell survival. Experiment Overall Design: Lymph node B cells were purified from Traf2 B cell knockout mice, Traf3 B cell knockout mice, Baff-tg mice and respective controls. RNA was extracted and hybridised to Affymetrix 430 2.0 Mouse Genome Arrays. Samples were processed and hence analysed on three spearate days. Day 1 two control mice: Traf2lox/lox pool and CD19-cretg were compared to two knockout mice: Traf2DB 80 and Traf3DB 94. On Day 2 three control mice: Traf2lox/lox 77, Traf2lox/lox 79 and Traf3lox/lox 97 were compared to two knockout mice: Traf2DB 76 and Traf3DB 01. On Day 3 three control mice: WT33, WT34, WT35 were compared to three Baff-tg mice: Baff-tg 99, Baff-tg 100, Baff-tg 101.

2008-04-07 | E-GEOD-10422 | biostudies-arrayexpress

Hepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice

2016-02-26 | GSE66717 | GEO

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