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Searching beyond the streetlight: neonicotinoid exposure alters the neurogenomic state of worker honey bees

ABSTRACT: Searching beyond the streetlight: neonicotinoid exposure alters the neurogenomic state of worker honey bees

PROVIDER: PRJNA740269 | ENA |

REPOSITORIES: ENA

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Searching beyond the streetlight: neonicotinoid exposure alters the neurogenomic state of worker honey bees

Project description:Neonicotinoid insecticides have been implicated in honey bee declines, with many studies showing that sub-lethal exposure impacts bee behaviors such as foraging, learning and memory. Despite the large number of ecotoxicological studies carried out to date, most focus on a handful of worker phenotypes leading to a ‘streetlight effect’ where the a priori choice of phenotypes to measure may influence the results and conclusions arising from the studies. This bias can be overcome with the use of toxicological transcriptomics, where changes in gene expression can provide a more objective view of how pesticides alter animal physiology. Here, we used RNA sequencing to examine the changes in neurogenomic states of nurse and forager honey bees that were naturally exposed to neonicotinoids in the field and artificially exposed to neonicotinoid in a controlled experiment.

2022-01-04 | GSE178742 | GEO

Searching beyond the streetlight: Neonicotinoid exposure alters the neurogenomic state of worker honey bees.

Project description: Not available

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Genetics of tolerance in honey bees to the neonicotinoid clothianidin.

Project description:The effects of neonicotinoid insecticides (NNIs) on honey bee health is intensely debated, with numerous studies showing negative effects of exposure, while others report no such effects. Understanding the cause of these differences is critical for developing evidence-based policy on the use of NNIs. We carried out experiments to study the genetic and molecular basis of NNI tolerance in honey bees, which may underlie the discrepancies observed in the literature. We discovered that worker survival post-exposure to an acute oral dose of clothianidin is heritable (H2=37.8%).

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Expression differences related to phenobarbital feeding in worker honey bees

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Expression differences related to phenobarbital feeding in worker honey bees

Project description:The drug phenobarbital induces cytochrome P450 monooxygenase (P450) gene expression in many animals, but no changes in P450 expression, or expression of any detoxification genes, were observed in worker honey bees fed on phenobarbital-candy relative to bees fed plain candy. Keywords: Expression profiling by array Five replicate microarray hybridizations were performed comparing transcript abundance in phenobarbital-fed and control-fed adult worker bees. Each total RNA pool was derived from an independent collection of 10 worker bees.

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cGMP modulates responses to queen mandibular pheromone in worker honey bees

Project description:Responses to social cues, such as pheromones, can be modified by genotype, physiology, or environmental context. Honey bee queens produce a pheromone (queen mandibular pheromone; QMP) which regulates many aspects of worker bee behavior and physiology. Forager honey bees are less responsive to QMP than young nurse bees engaged in brood care, suggesting that physiological changes associated with behavioral maturation may modulate response to this pheromone. Since cGMP is a major regulator of behavioral maturation in honey bee workers, we examined its role in modulating worker responses to QMP. Treatment with a cGMP analog, 8-Br-cGMP, resulted in significant reductions in both behavioral and physiological responses to QMP in young caged workers. Treatment significantly reduced attraction to QMP (the retinue response) and inhibited the QMP-mediated increase in vitellogenin levels in the fat bodies of worker bees. Genome-wide analysis of brain gene expression patterns demonstrated that cGMP has a larger effect on expression levels than QMP, and that QMP has specific effects in the presence of cGMP, suggesting that some responses to QMP may be dependent on an individual beesM-^R physiological state. Several functional gene categories were significantly differentially expressed, including genes involved in regulating GTPase activity, phototransduction, immunity, and carboxylic acid transmembrane transporter activity. Overall, our data suggest that cGMP-mediated processes play a large role in modulating responses to queen pheromone in honey bees, at the behavioral, physiological and molecular levels.

2011-06-15 | E-MEXP-3135 | biostudies-arrayexpress

RNA-Seq of full-length RNA from worker and royal jelly of honey bees (Apis mellifera)

Project description:Characterization of naturally-occurring RNAs (up to 200nt) in the honey bee worker and royal jelly

2018-11-29 | E-MTAB-6557 | biostudies-arrayexpress

Molecular effects of neonicotinoid thiacloprid in honey bees (Apis mellifera)

Project description:Molecular effects of neonicotinoid thiacloprid in honey bees (Apis mellifera)

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Transcription profiling of abdomens from wild type and anarchistic strains of worker honey bees to identify genes related to ovary activation

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2008-12-09 | E-MEXP-1549 | biostudies-arrayexpress

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