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Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Skin)

ABSTRACT: Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Skin)

PROVIDER: PRJNA740314 | ENA |

REPOSITORIES: ENA

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Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Project description:Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

| PRJNA740308 | ENA

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Liver)

Project description:Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Liver)

| PRJNA740313 | ENA

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Salivary Gland)

Project description:Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Salivary Gland)

| PRJNA740312 | ENA

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Skin)

Project description:Tissue-resident memory T cells (TRM) are non-recirculating cells that exist throughout the body. While TRM in various organs rely on common transcriptional networks to establish tissue residency, location-specific factors adapt these cells to their tissue of lodgment. Here, we chart TRM heterogeneity between organs and find that the different environments in which these cells differentiate dictate TRM function, durability and malleability. We find that unequal responsiveness to TGF-β is a major driver of this diversity. Strikingly, dampened TGF-b signaling engendered CD103- TRM with increased proliferative potential, enhanced function, and reduced longevity compared to their TGF-β-responsive CD103+ TRM counterparts. Further, while CD103- TRM readily modified their phenotype upon relocation, CD103+ TRM were comparatively resistant to trans-differentiation. Thus, despite common requirements for TRM development, adaptation of these cells to their tissue of residence confers discrete functional properties such that TRM exist along a spectrum of differentiation potential that is governed by their local microenvironment.

2021-06-24 | GSE178768 | GEO

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Liver)

2021-06-24 | GSE178767 | GEO

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity (Salivary Gland)

2021-06-24 | GSE178766 | GEO

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-24 | GSE178769 | GEO

Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation

Project description:Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation

| PRJNA759863 | ENA

Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation [scRNA-seq]