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Detection Novel miRNA Potentially Involved in Proximal Tubules under Hypoxia Using Next-Generation Sequencing and Bioinformatic Approaches

ABSTRACT: Detection Novel miRNA Potentially Involved in Proximal Tubules under Hypoxia Using Next-Generation Sequencing and Bioinformatic Approaches

PROVIDER: PRJNA741124 | ENA |

REPOSITORIES: ENA

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Detection Novel miRNA Potentially Involved in Proximal Tubules under Hypoxia Using Next-Generation Sequencing and Bioinformatic Approaches

Project description:MicroRNAs are hypothesized to play critical roles in the regulation ofhypoxia-induced proximal tubular injury. The aim of this study is to explore novel microRNAs differentially expressed in HK-2 cells under normoxia and hypoxia conditions. RNAs were extracted from HK-2 cells cultured under normoxia and hypoxia for sequencing. Using the next generation sequencing and bioinformatics approaches, we identified 11 differentially expressed microRNAs in HK-2 cells under hypoxia condition.

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Gene expression profiles in isolated proximal tubules and whole kidneys of rats after cisplatin-administration

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