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Transcriptome analysis of adult wildtype and pdx1+/- zebrafish kidneys through next generation RNA sequencing

ABSTRACT: Transcriptome analysis of adult wildtype and pdx1+/- zebrafish kidneys through next generation RNA sequencing

PROVIDER: PRJNA742218 | ENA |

REPOSITORIES: ENA

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Transcriptome analysis of adult wildtype and pdx1+/- zebrafish kidneys through next generation RNA sequencing

Project description:The pdx1 knockout zebrafish mutant has been established as an animal model of diabetic retinopathy. Due to a disturbed beta cell development these mutants develop hyperglycaemia leading to an activation of angiogenesis in the retina of larval and adult stages. This study addresses the questions if the pdx1 heterozygous mutant kidney is also affected by similar changes of the microvasculature and if the expression patterns of signaling pathways and mechanisms associated with the development of diabetic conditions are changed in these kidneys. For this purpose we performed RNA sequencing with the mRNA of total adult kidneys of heterozygous pdx1 mutants and their wildtype littermates.

2022-04-05 | GSE179104 | GEO

Gene expression profiling of endothelial cells isolated from wildtype and Crim1KST264/KST264 adult mice kidneys

Project description:Previous analysis has shown that the Crim1KST264/KST264 mice develop progressive renal fibrosis as well as vascular abnormalities characterised by increased vascular leakiness and loss of endothelium integrity. To further define this endothelium abnormality, CD31+ endothelial cells were MACS sorted from both wildtype and Crim1KST264/KST264 kidneys for expression profiling to determine the biological processes that are perturbed. Total RNA was extracted from CD31+ MACS sorted endothelial cells from 4 pairs of mixed gender wildtype and Crim1KST264/KST264 adult mice kidneys

2012-12-12 | E-GEOD-37606 | biostudies-arrayexpress

Next Generation Sequencing Facilitates Quantitative Analysis of pancreatic tissue transcriptomes from KrasG12D;Pdx1-Cre and miR-301a-/-;KrasG12D;Pdx1-Cre mice treated with caerulein

Project description:Purpose: we used next generation sequencing to analyze gene expression profiles of pancreatic tissues from KrasG12D;Pdx1-Cre and miR-301a-/-;KrasG12D;Pdx1-Cre mice treated with caerulein. The goals of this study are to compare the different gene expression profiles of pancreatic tissue between KrasG12D;Pdx1-Cre and miR-301a-/-;KrasG12D;Pdx1-Cre mice treated with caerulein.

2021-06-11 | GSE176571 | GEO

Gene expression profiling of endothelial cells isolated from wildtype and Crim1KST264/KST264 adult mice kidneys

2012-12-12 | GSE37606 | GEO

Next Generation Sequencing of PKD2 mutant mice kidneys

Project description:This Study sought to understand the differential gene expression profile of Pkd2 mutant mice kidneys in the setting of miR-21 deletion 4 Wild type mice, 3 Pkd2 Knockout mice and 3 Pkd2-miR-21 knockout mice were analyzed

2016-01-05 | E-GEOD-69556 | biostudies-arrayexpress

Next Generation Sequencing of Pkd1 mutant kidneys

Project description:This study sough to understand the differential gene expression profile of Pkd1 mutant mice kidneys in the setting of miR 17~92 deletion

2017-06-12 | GSE89764 | GEO

Next Generation Sequencing of PKD2 mutant mice kidneys

Project description:This Study sought to understand the differential gene expression profile of Pkd2 mutant mice kidneys in the setting of miR-21 deletion

2016-01-05 | GSE69556 | GEO

Next Generation Sequencing Analysis of Prenatal Chlorpyrifos Exposure embryonic kidneys

Project description:Purpose: In order to study signaling pathway changes of prenatal chlorpyrifos exposure embryonic kidney development Methods: By using RNA-seq, we studied the transcriptome of E12.5, E14.5, E16.5 and E18.5 prenatal chlorpyrifos exposure embryonic kidneys and DMSO exposure (control) embryonic kidneys Results: We show that Notch signaling pathway and aquaporin family had high expression in chlorpyrifos exposure E18.5 kidney. The nephron progenitor markers had low expression in chlorpyrifos exposure embryonic kidneys

2019-06-30 | GSE131263 | GEO

Whole kidneys at embryonic day 14.5: wildtype (WT) versus Hoxb7Cre transgene mediated conditional Mdm4 knockout kidneys

Project description:Whole kidneys at embryonic day 14.5: wildtype (WT) versus Hoxb7Cre transgene mediated conditional Mdm4 knockout kidneys

| PRJNA574125 | ENA

RNA sequencing of Foxd1Cre;Smo(flox/-) mutant kidneys

Project description:Purpose: To analyze the mRNA content of Foxd1Cre;Smo(flox/-) mutant kidneys. Methods: We collected E13.5 wildtype and Foxd1Cre;Smo(flox/-) mutant kidneys and isolated RNA to do RNA-Seq. Results: Identified differentially expressed transcripts in Foxd1Cre;Smo(flox/-) mutant kidneys compared to wildtype controls. Conclusions: Our work provides novel insight into how Hedgehog signaling from stromal cells influences renal development.

2018-06-26 | GSE103923 | GEO

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