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Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

ABSTRACT: Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

PROVIDER: PRJNA745569 | ENA |

REPOSITORIES: ENA

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Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

Project description:Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

| PRJNA725513 | ENA

Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

Project description:Reducing mitochondrial electron transport induces a Warburg-like shift to accommodate for the energetic burden caused by brain trauma and salvage dopaminergic neurons. This metabolic shift is evident in the transcriptional upregulation of key genes in the Pyruvate Dehydrogenase Complex and glycolytic pathway.

2021-08-26 | GSE173431 | GEO

Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

Project description:Reducing mitochondrial electron transport induces a Warburg-like shift to accommodate for the energetic burden caused by brain trauma without overwhelming mitochondrial cellular respiration and cellular redox to salvage dopaminergic neurons. This metabolic shift is evident in the transcriptional upregulation of key genes in the Pyruvate Dehydrogenase Complex and glycolytic pathway.

2021-08-26 | GSE179905 | GEO

Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration.

Project description: Not available

| S-EPMC8448530 | biostudies-literature

TREM2 shapes myeloid cell activations in trauma- and autoimmune-mediated neurodegeneration

Project description:TREM2 signaling in myeloid cells functions as a major pathology-induced immune signaling hub in trauma- and autoimmune-mediated neurodegeneration. Here we compared the influence of TREM2 signaling on single-cell transcriptional profiles of mouse myeloid populations during the pathologies of spinal cord injury (SCI) and multiple sclerosis (MS) models.

2023-06-06 | GSE198852 | GEO

Blast preconditioning protects retinal ganglion cells and reveals targets for prevention of neurodegeneration following blast-mediated TBI

Project description:Purpose: The purpose of this study was to examine the effect blast preconditioning on the structure and function of retinal ganglion cells (RGC), and to identify molecular pathways that contribute to RGC loss. Methods: To examine the effect of blast-preconditioning three groups of mice were analyzed, including those 1) subjected to sham injury followed by one single 20 PSI injury one week later, 2) mice exposed to two low intensity preconditioning blast exposures separated by one week (5 PSI, 5 PSI) and 3) mice exposed to a preconditioning injury (5 PSI) followed by a single 20 PSI blast exposure one week later. RNAseq analysis was used to identify transcriptional changes between groups. Conclusions: Preconditioning protects RGC from blast injury. Protective effects appear to involve changes in kynurenine-3-monooxygenase activity, whose inhibition is also protective.

2019-09-24 | GSE133940 | GEO

Genomics of preconditioning

Project description:Isolated perfused rat hearts exposed to isoflurane or ischemic preconditioning, a subgroup followed by 40 minutes of ischemia and 3 hours of reperfusion. Exact protocol available from the authors. Keywords = preconditioning Keywords = anesthetics Keywords = ischemia/reperfusion Keywords: other

2004-07-30 | GSE1616 | GEO

Transcriptional Profile of Microglia in Neurodegeneration

Project description:Purpose: RNASeq was used to identify transcriptional signature responsible for the metabolic reprogramming phenotype of microglia in neurodegenerative disease Result: We identified Ppargc1a/Cebpb signaling pathway as a critical axis that controls microglial glycolytic transition during neurodegeneration

2020-08-28 | GSE92550 | GEO

Preconditioning Biochar-Fungal analyses

Project description:Preconditioning Biochar-Fungal analyses

| PRJNA415278 | ENA

Burn/Trauma Study

Project description:#G017 Burn/Trauma Study. This is a Glue Grant Study comparison between gene expression analyses performed in eight trauma/burn subjects using either a buffy coat isolation of whole blood or using the PAXgene system Keywords: other

2004-04-24 | GSE1343 | GEO

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