Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Porphyromonas gingivalis alters gene expressions in the liver and brown adipose tissue, and induces gestational obesity and underweight of fetus in pregnant mice [BAT]

ABSTRACT: Porphyromonas gingivalis alters gene expressions in the liver and brown adipose tissue, and induces gestational obesity and underweight of fetus in pregnant mice [BAT]

PROVIDER: PRJNA746588 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Porphyromonas gingivalis alters gene expressions in the liver and brown adipose tissue, and induces gestational obesity and underweight of fetus in pregnant mice [Liver]

Project description:Porphyromonas gingivalis alters gene expressions in the liver and brown adipose tissue, and induces gestational obesity and underweight of fetus in pregnant mice [Liver]

| PRJNA746992 | ENA

Porphyromonas gingivalis alters gene expressions in the liver and brown adipose tissue, and induces gestational obesity and underweight of fetus in pregnant mice [BAT]

Project description:The aim of this study was to evaluate the effect of oral and intravenous administration of sonicated P.gingivalis to the liver and brown adipose tissue tissueof pregnant mice

2021-10-31 | GSE180115 | GEO

Porphyromonas gingivalis alters gene expressions in the liver and brown adipose tissue, and induces gestational obesity and underweight of fetus in pregnant mice [Liver]

Project description:The aim of this study was to evaluate the effect of oral and intravenous administration of sonicated P.gingivalis to the liver and brown adipose tissue tissueof pregnant mice

2021-10-31 | GSE180189 | GEO

LFQ of Campylobacter fetus subsp. fetus strains

Project description:Comparsion of proteomes of Campylobacter fetus subsp. fetus to compare protein level via iBAQ analysis, expression (by LFQ) and coverage between Campylobacter fetus subsp. fetus strain82-40 vs Campylobacter fetus subsp. fetus strain ATCC 27374

2020-05-25 | PXD014538 | Pride

Porphyromonas gingivalis comparative genomic hybridization

Project description:Genotyping studies suggest that there is genetic variability among P. gingivalis strains, however the extent of variability remains unclear, and the regions of variability have only partially been identified. We previously used heteroduplex analysis of the ribosomal operon intergenic spacer region (ISR) to type P. gingivalis strains in several diverse populations, identifying 6 predominant heteroduplex types and many minor ones. In addition we used ISR sequence analysis to determine the relatedness of P. gingivalis strains to one another, and demonstrated a link between ISR sequence phylogeny and the disease-associated phenotype of P. gingivalis strains. The availability of whole genome microarrays based on the genomic sequence of strain W83 has allowed a more comprehensive analysis of P. gingivalis strain variability, using the entire genome. The objectives of this study were to define the phylogeny of P. gingivalis strains using the entire genome, to compare the phylogeny based on genome content to the phylogeny based on a single locus (ISR), and to identify genes that are associated with the strongly disease-associated strain W83 that could be important for virulence. Keywords: Comparative genomic hybridization

2008-10-09 | GSE13128 | GEO

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [RNAseq]

Project description:Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric disease. Exposure of cultured neurons to fetal plasma or to secretions from the placenta or from model trophoblast barriers that had been exposed to altered oxygenation caused similar morphological changes. The secretions and plasma contained altered microRNAs whose targets were linked with changes in gene expression in the fetal brain and with human schizophrenia loci. Molecular and morphological changes in vivo and in vitro were prevented by a single dose of MitoQ bound to nanoparticles, which were shown to localise and prevent oxidative stress in the placenta but not in the fetus. We suggest the possibility of developing preventative treatments that target the placenta and not the fetus to reduce risk of psychiatric disease in later life.

2017-08-22 | GSE86408 | GEO

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [microRNA]

2017-08-22 | GSE86346 | GEO

Porphyromonas gingivalis comparative genomic hybridization

2010-05-18 | E-GEOD-13128 | biostudies-arrayexpress

Role of PG1626 in Porphyromonas gingivalis ATCC33277

Project description:Wild type Porphyromonas gingivalis strain ATCC33277 (V3176) and PG1626 - deficient mutant (V3177) were grown in iron replete conditions was used to compare to Porphyromonas gingivalis strains grown in iron chelated conditions.

2023-06-08 | GSE174493 | GEO

Human Trophoblast Responses to P. gingivalis Infection

Project description:Porphyromonas gingivalis is a periodontal pathogen that is also associated with preterm low birth weight delivery. We investigated the transcriptional responses of human extravillous trophoblasts (HTR-8) to infection with P. gingivalis. Over 2000 genes were differentially regulated in HTR-8 cells by P. gingivalis. In ontology analyses of regulated genes, overpopulated biological pathways included MAP kinase signaling and cytokine production. Immunoblots confirmed over expression of the MAP kinase pathway components MEK3, p38 and Max. Furthermore, P. gingivalis infection induced phosphorylation and activation of MEK3 and p38. Increased production of IL-1β and IL-8 by HTR-8 cells was demonstrated phenotypically by ELISA of HTR-8 cell lysates and culture supernatants. Thus infection of trophoblasts by P. gingivalis can impact signal transduction pathways and modulate cytokine expression, outcomes that could disrupt the maintenance of pregnancy.

2010-11-02 | GSE19810 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data