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Gene expression analysis in complex canine chronic cutaneous lupus erythematosus (CCLE)

ABSTRACT: Gene expression analysis in complex canine chronic cutaneous lupus erythematosus (CCLE)

PROVIDER: PRJNA747302 | ENA |

REPOSITORIES: ENA

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Gene expression analysis in complex canine chronic cutaneous lupus erythematosus (CCLE)

Project description:We performed a comparative immunology case study of client-owned dogs to determine if immune and skin gene expression profiles in spontaneous canine chronic cutaneous lupus erythematosus (CCLE) with concomitant systemic autoimmunity mirror those observed in human CCLE.

2022-02-11 | GSE180276 | GEO

Gene expression analysis in canine discoid/chronic lupus erythematosus, mucocutaneous lupus erythematosus and lupoid drug reaction

Project description:We performed a comparative immunology case study of client-owned dogs to determine if immune and skin gene expression profiles in spontaneous canine cutaneous lupus erythematosus mirror those observed in human cutaneous lupus.

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Spatial transcriptomics of Cutaneous and Systemic Lupus Erythematosus skin

Project description:We performed spatial transcriptomics on a case series of different clinical subtypes of cutaneous lupus erythematosus including acute cutaneous lupus erythematosus (malar rash, systemic lupus erythematosus). Our goals were to (1) determine which differentially expressed genes (DEGs) could be attributed to specific cell populations in specific locations within the tissue, (2) determine if spatial transcriptomics could better distinguish between CLE clinical subtypes than bulk RNA approaches and (3) examine potential cell-cell communication pathways within the skin lesions.

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Gene expression in cutaneous lupus erythematosus

Project description:Lesional skin biopsies were taken from patients with active, untreated lupus skin disease (chronic discoid lupus erythematosus, CDLE, n=6; subacute cutaneous lupus erythematosus, SCLE, n=5). Healthy control specimens (HC) were obtained from healthy skin of 5 patients undergoing plastic surgery. In every case, two 4mm punch biopsies were taken. One was flash-frozen in liquid nitrogen and afterwards processed for mRNA isolation. The second biopsy was fixed in 5% formalin solution overnight, and was proceeded for histological investigation.The one-color Agilent 60-mer oligo microarray (Agilent, Santa Clara, CA) was used for gene expression analyses. Statistical analyses were performed using the Agilent Feature Extraction Softwareâ¢ and the Rosetta Resolverâ¢ gene expression data analysis system. The presented gene list (Table S1) includes normalized sample/ control log10-ratios (expression > 2-fold enhanced, p<0.01).

2017-02-24 | E-MTAB-5542 | biostudies-arrayexpress

Genome-wide analysis of gene expression of cutaneous lupus skin samples and lupus nephritis kidney samples

Project description:Microarray gene expression analyses were performed on human skin samples from cutaneous lupus subtypes (SCLE and CCLE) and normal patients along with human kidney samples from lupus nephritis and normal patients

2021-04-22 | GSE112943 | GEO

Gene expression analysis in canine discoid/chronic lupus erythematosus, mucocutaneous lupus erythematosus and lupoid drug reaction

Project description:Gene expression analysis in canine discoid/chronic lupus erythematosus, mucocutaneous lupus erythematosus and lupoid drug reaction

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Targeted proteomics analysis of Cutaneous Lupus Erythematosus patient interstitial skin fluid and plasma (Inflammation panel data)

Project description:We performed a targeted proteomics analysis of Cutaneous Lupus Erythematosus (CLE) patient blister biopsies and plasma using Olink Proteomics panels to validate the blister biopsy technique using previously identified biomarkers, to confirm protein-level expression of biomarkers previously identified at the RNA level, and to identify new biomarkers of disease.

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Targeted proteomics analysis of Cutaneous Lupus Erythematosus patient interstitial skin fluid and plasma (Neuro Exploratory panel data)

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Spatial transcriptomics of Cutaneous and Systemic Lupus Erythematosus skin

Project description:Spatial transcriptomics of Cutaneous and Systemic Lupus Erythematosus skin

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To study glycosaminoglycan (GAG) glycogene expression in cutaneous lupus erythematosus (CLE) skin lesions and normal skin

Project description:Cutaneous lupus erythematosus (CLE) is an autoimmune disease that localizes to the skin and is known to contain elevated glycosaminoglycans (GAGs) on Hale’s stain of skin biopsy specimens. Recently, different GAG species have been shown to have distinct effects on the recruitment and activation of immune cells and stimulation of cytokine production (Taylor and Gallo, FASEB, 2006; 20: 9-22). Thus, we speculate that the elevated GAGs observed in CLE play a role in the local inflammatory process that produces skin lesions in these patients.

2011-06-14 | GSE29938 | GEO

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