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Transcriptional dynamics in primary human monocytes exposed to thyroid hormone ex vivo

ABSTRACT: Transcriptional dynamics in primary human monocytes exposed to thyroid hormone ex vivo

PROVIDER: PRJNA749242 | ENA |

REPOSITORIES: ENA

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Transcriptional dynamics in primary human monocytes exposed to thyroid hormone ex vivo

Project description:Trained immunity is a phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to certain microbial components, altering their responses to future exposures. This study profiled the transcriptome of human monocytes exposed to thyroid hormone for 24 hours.

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DNA methylation dynamics in primary human monocytes exposed to thyroid hormone ex vivo

Project description:Trained immunity is a phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to certain microbial components, altering their responses to future exposures. This study profiled the genome-wide DNA methylation profile of human monocytes exposed to thyroid hormone for 24 hours.

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DNA methylation dynamics in primary human monocytes exposed to thyroid hormone ex vivo

Project description:DNA methylation dynamics in primary human monocytes exposed to thyroid hormone ex vivo

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DNA methylation and transcriptional dynamics in primary human monocytes exposed to thyroid hormone ex vivo

Project description:DNA methylation and transcriptional dynamics in primary human monocytes exposed to thyroid hormone ex vivo

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Thyroid hormone receptor beta is required for thyrotrpin regulation and thyroid hormone production.

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Thyroid hormone receptor alpha is required for thyroid hormone-dependent neural cell proliferation during tadpole metamorphosis

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Thyroid hormone receptor a in skeletal muscle is essential for thyroid thermogenesis

Project description:Thyroid hormones are important for homeostatic control of energy metabolism and body temperature. Although skeletal muscle is considered an important site for thyroid action, the contribution of thyroid hormone receptor signaling, in muscle, to whole-body energy metabolism and body temperature has not been resolved. Here, we show that thyroid hormone-induced increase in energy expenditure requires thyroid hormone receptor alpha 1 (TRa1) in skeletal muscle, but that thyroid hormone induced elevation in body temperature is independent of muscle-TRa1. In slow-twitch soleus muscle, ablation of TRa1 leads to an altered fiber type composition toward a more oxidative phenotype, which, however, does not influence running capacity or motivation to voluntary running. RNA-sequencing of soleus muscle from WT mice and TRaHSACre mice revealed differentiated transcriptional regulation of genes associated with muscle thermogenesis, such as sarcolipin and UCP3, thus providing molecular clues pertaining to the mechanistic underpinnings of TRa1-linked control of whole-body metabolic rate. Together, this work establishes a fundamental role for skeletal muscle in thyroid hormone-stimulated increase in whole-body energy expenditure.

2020-09-21 | GSE146336 | GEO

Target genes of thyroid hormone in cerebellum neurons

2012-03-30 | GSE24793 | GEO

DNA methylation and transcriptional dynamics in primary human monocytes exposed to thyroid hormone ex vivo

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-06 | GSE180694 | GEO

Target genes of thyroid hormone in cerebellum neurons

Project description:Cerebellar post-natal development is particularly sensitive to thyroid hormone and low levels of thyroid hormone (hypothyroidism) result in permanent defects in cerebellar architecture and function. All cell types of the cerebellum are affected, but the main sign of hypothyroidism in mice is the persistence of the external granular layer, composed of mitotic neuronal precursors at P21. To make the genetic link between thyroid hormone and cerebellar development, we sought to identify new thyroid hormone target genes, in particular in granule cells which represent the vast majority of cerebellar cells. Primary cultures of cerebellar neurons were made by dissociation of cerebella from newborn wild-type mice. These cells were plated 48 hours in serum-free medium to avoid invasion of the culture by glial cells. In order to include a kinetic and a maximum number of target genes, several cultures were either treated or left untreated as controls for 6 hours (T1), 16 hours (T2), 24 hours (T3) or 48 hours (T4) and results were pairwise compared for each time point.

2012-03-29 | E-GEOD-24793 | biostudies-arrayexpress

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