Project description:Cutaneous T cell lymphoma (CTCL) is characterized by the proliferation of CD4+ T cells in a background of chronic inflammation, where malignant CTCL cells escape immune surveillance and are not eliminated. To study how miRNAs (miRs) regulate T cell exhaustion in this disease, we performed miRseq analysis, qRT-PCR, and in situ hybridization on 45 primary CTCL samples, 3 healthy skin samples, and CTCL cell lines, identifying miR-155-5p, -130b-3p and -21-3p. Moreover, miR-155-5p, -130b-3p, and -21-3p positively correlated with immune checkpoint gene expression in lesional skin samples and were enriched in the IL6/JAK/STAT signaling pathway by gene set enrichment analysis.

2021-12-07 | GSE181118 | GEO

MiRNA regulation of T cell exhaustion in cutaneous T cell lymphoma [cell line]

Project description:To study how miRNAs (miRs) regulate T cell exhaustion, we performed miRseq analysis, and RNAseq on CTCL cell lines.

2021-08-04 | GSE180574 | GEO

Study of cutaneous biology of cutaneous T cell lymphoma

Project description:Study of cutaneous biology of cutaneous T cell lymphoma

| PRJNA785680 | ENA

Study of cutaneous biology of cutaneous T cell lymphoma

Project description:Study of cutaneous biology of cutaneous T cell lymphoma

| PRJNA785707 | ENA

Single-cell profiling of cutaneous T-cell lymphoma

Project description:Single-cell profiling of cutaneous T-cell lymphoma

| PRJNA514234 | ENA

Gene Expression Profiles of cutaneous B-cell lymphoma

Project description:We studied gene expression profiles of 17 cutaneous B-cell lymphomas that were collected with 4-6 millimeter skin punch biopsies. We also included tissue from 2 cases of mycosis fungoides (MF), 3 normal skin biopsies and 3 tonsils to create a framework for further interpretation. A hierarchical cluster algorithm was applied for data analysis. Our results indicate that small amounts of skin tissue can be used successfully to perform microarray analysis and result in distinct gene expression patterns. Duplicate specimens clustered together demonstrating a reproducible technique. Within the cutaneous B-cell lymphoma specimens two specific B-cell differentiation stage signatures of germinal center B-cells and plasma cells could be identified. Primary cutaneous follicular and primary cutaneous diffuse large B-cell lymphomas had a germinal center B-cell signature while a subset of marginal zone lymphomas demonstrated a plasma cell signature. Primary and secondary follicular B-cell lymphoma of the skin were closely related, despite previously reported genetic and phenotypic differences. In contrast primary and secondary cutaneous diffuse large B-cell lymphoma were less related to each other. This pilot study allows a first glance into the complex and unique microenvironment of B-cell lymphomas of the skin and provides a basis for future studies, that may lead to the identification of potential histologic and prognostic markers as well as therapeutic targets. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed

2005-12-16 | E-GEOD-3827 | biostudies-arrayexpress

Gene Expression Profiles of cutaneous B-cell lymphoma

2005-12-17 | GSE3827 | GEO

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