Genomics

Dataset Information

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Epithelial memory of resolved inflammation limits tissue damage while promoting pancreatic tumorigenesis [scRNA-Seq]


ABSTRACT: Epithelial memory of resolved inflammation limits tissue damage while promoting pancreatic tumorigenesis [scRNA-Seq]

PROVIDER: PRJNA751384 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR15319355_1.fastq.gz Fastqsanger.gz
SRR15319355_2.fastq.gz Fastqsanger.gz
SRR15319356_1.fastq.gz Fastqsanger.gz
SRR15319356_2.fastq.gz Fastqsanger.gz
SRR15319357_1.fastq.gz Fastqsanger.gz
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Publications


Inflammation is a major risk factor for pancreatic ductal adenocarcinoma (PDAC). When occurring in the context of pancreatitis, KRAS mutations accelerate tumor development in mouse models. We report that long after its complete resolution, a transient inflammatory event primes pancreatic epithelial cells to subsequent transformation by oncogenic KRAS. Upon recovery from acute inflammation, pancreatic epithelial cells display an enduring adaptive response associated with sustained transcriptional  ...[more]

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