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The RNA-seq result of GC cells which were treated with chrysin

ABSTRACT: The RNA-seq result of GC cells which were treated with chrysin

PROVIDER: PRJNA752168 | ENA |

REPOSITORIES: ENA

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The RNA-seq result of GC cells which were treated with chrysin

Project description:Chrysin has been reported to have anticancer effect. We used 40μM chrysin to treat SGC7901 cells for 48h, then sequenced their RNA, analyzed the differentially expressed genes before and after treatment, screened out the anticancer target of chrysin, and then carried on the next analysis

2021-08-19 | GSE181492 | GEO

The transcriptome sequencing of Chrysin treated Scc9 Extracellular vesicles

Project description:EVs-Chrysin(Chrysin-treated SCC9) were isolated from SCC9 cells that were treated with chrysin. To improve the therapeutic effect, AuNPs were carried by EVs-Chrysin (Au-EVs). Compared to BGC823 and HCC-LM3 cells, the uptake of Au-EVs were specific in SCC9 cells. Moreover, Au-EVs combined with NIR enhanced cell apoptosis in TSCC cells. To confirm the role of miRNAs in cell apoptosis, the differentially expressed miRNAs between EVs-Con and EVs-Chrysin were screened by RNA-seq.

2021-10-12 | GSE185562 | GEO

RNA-seq analysis of A549 cells treated with chrysin or nifurtimox

Project description:The influences of 40 hours treatment of 30 μM chrysin (CAS No: 480-40-0) or 30 μM nifurtimox (CAS No: 23256-30-6) on A549 cell gene expression profile were examined by RNA sequencing.

2022-03-01 | GSE193541 | GEO

RNA-seq analysis of A549 cells treated with chrysin or nifurtimox

Project description:RNA-seq analysis of A549 cells treated with chrysin or nifurtimox

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The transcriptome sequencing of Chrysin treated Scc9 Extracellular vesicles

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Transcriptome analysis following Apigenin and Chrysin treatment of Mouse Embryonic Fibroblasts

Project description:There is no known single therapeutic drug for treating hypercholesterolemia that comes with negligible systemic side effects. In the current study, using next generation RNA sequencing approach in mouse embryonic fibroblasts we discovered that two structurally related flavonoid compounds, Apigenin and Chrysin exhibited moderate blocking ability of multiple transcripts that regulate rate limiting enzymes in the cholesterol biosynthetic pathway. The observed decrease in cholesterol biosynthesis pathway correlated well with an increase in transcripts involved in generation and trafficking of ketone bodies as evident by the upregulation of Bdh1 and Slc16a6 transcripts. Impact statement - The hypocholesterolemic potential of Apigenin and Chrysin at higher concentrations along with their ability to generate ketogenic substrate especially during embryonic stage is useful or detrimental for embryonic health is not clear and still debatable. Our findings will set the stage for translating this information to whole animal and clinical studies that could shed light to the existing information regarding safe use of Apigenin and Chrysin, specifically to embryonic health.

2021-08-09 | GSE155852 | GEO

Expression data from Green cells (BT-GC) -treated HFDPCs

Project description:Gene expression profiling reveals a potential role of Green cells (BT-GC) in stimulating hair growth in dermal papilla cells. HFDPCs were human primary cells line, treated with 1:2000 Green cells (BT-GC) for 48 h. Microarray gene expression profiling was conducted for three biological replicates

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Comprehensive transcriptome analysis of heart tissues in the sugen/hypoxia rats with/without treatment of chrysin

Project description:Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remodeling leading to increased pulmonary vascular resistance and right ventricular (RV) hypertrophy, resulting in RV failure. RV dysfunction is a complex process that leads to cardiomyocyte hypertrophy, fibrosis, inflammation, angiogenesis, and metabolic changes. In patient with PAH, the adaptation of the RV to high pulmonary arterial pressures is the most important determinant of prognosis. However, the underlying molecular mechanism of adverse RV remodeling and dysfunction is poorly understood, and there are no currently approved therapies that improve RV function. Chrysin (5,7-dihydroxyflavone) is a phytochemical, which is a flavonoid widely present in plant sources. In various experimental models chrysin has shown to exert cardio-protective effects through its antioxidant and anti-inflammatory effects. In this study, we performed a comprehensive analysis of gene expression changes in heart tissues of rats under hypoxic conditions with chrysin treatment using RNA sequencing (RNA-seq).

2022-02-15 | GSE186989 | GEO

Expression data from Green cells (BT-GC) -treated HFDPCs

Project description:Expression data from Green cells (BT-GC) -treated HFDPCs

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