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MiRNAs in MSCs-exosome compared with NIH3T3-exosome

ABSTRACT: miRNAs in MSCs-exosome compared with NIH3T3-exosome

PROVIDER: PRJNA752363 | ENA |

REPOSITORIES: ENA

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miRNAs in MSCs-exosome compared with NIH3T3-exosome

Project description:We report the application of Microarray analysis using micro RNAs in esoxomes from mouse bone marrow derived mesenchymal stem cells (MSCs) and NIH3T3 cells were compared

2021-08-07 | GSE181530 | GEO

Murine MSCs: MSC-exosome-hypoxia vs MSC-exosome-normoxia

Project description:Murine MSCs: MSC-exosome-hypoxia vs MSC-exosome-normoxia

| PRJNA490327 | ENA

Nutrient-dependent growth of NIH3T3 and NIH3T3 K-ras cell lines.

Project description:Expression profiling of normal NIH3T3 and transformed NIH3T3 K-ras cell lines grown for 72 hours in optimal glucose availability (25 mM glucose) or low glucose availability (1 mM). Low glucose induces apoptosis in transformed cells as compared to normal ones.

2011-07-14 | GSE29962 | GEO

Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis

Project description:Multiple myeloma (MM) is characterized by the impaired osteogenic differentiation of mesenchymal stem cells (MSCs). Stromal communication with cancer cells can influence treatment response. Understanding the cellular interactions within the tumor-bone milieu is critical to the development of novel agents that can reverse bone diseases. Here we identified that bioactive lncRNA RUNX2-AS1 in myeloma cells could be incorporated into exosomes and transmitted to MSCs, thus repressing the osteogenesis of MSCs. RUNX2-AS1, which arises from the antisense strand of RUNX2, was enriched in MSCs derived from MM patients (MM-MSCs). RUNX2-AS1 was capable of forming an RNA duplex with RUNX2 pre-mRNA at overlapping regions and this duplex transcriptionally repressed RUNX2 expression by reducing the splicing efficiency, resulting in decreased osteogenic potential of MSCs. In vivo mouse models, intraperitoneally administered GW4869, an inhibitor of exosome secretion, was found to be effective in prevention of bone loss, sustained by both bone-forming and anticatabolic activities. Therefore, exosomic lncRNA RUNX2-AS1 may serve as a potential therapeutic target for bone lesions in MM. In summary, our results indicated a unique role of exosomic lncRUNX2-AS1 in transferring from MM cells to MSCs in osteogenic differentiation, through a novel exosomic lncRUNX2-AS1/RUNX2 signaling pathway.

2020-12-15 | GSE108159 | GEO

Expression Signature and Regulatory Role of miRNAs in Hepatocellular Carcinoma-Induced Cancer Associated Fibroblasts

Project description:The study aims to assess the influence of soluble factors from HCC on MSCs and to investigate the regulatory effect of miRNAs in human adipose- MSCs (hA-MSCs) cultured in HCC microenvironment.The results suggest an interaction between tumor cells and the surrounding stromal components and provide evidence to the direct generation of CAF phenotype upon exposure of hA-MSCs to Huh-7 cancer microenvironment, favoring cancer progression. This might shed the light on the fate of hA-MSCs use in therapy in HCC. hA-MSCs modulation may be achieved via dysregulation of miR17-5P and 615-5p expression. These data suggest that miRNAs may present a new target for HCC treatment.

2022-04-19 | PXD024418 | Pride

Urinary miRNAs contained in exosome of dogs and cats

Project description:Urinary miRNAs contained in exosome of dogs and cats

| PRJNA495859 | ENA

Transcription profiling of oncovav- and oncovav2-transformed NIH3T3 cells vs parental NIH3T3 controls

Project description:Effect of the overexpression of the oncogenic forms of the Vav2 and Vav proteins in the NIH3T3 cell line. oncovav- and oncovav2-transformed NIH3T3 cells are compared to the parental NIH3T3 controls under exponential growth conditions

2005-06-22 | E-MEXP-135 | biostudies-arrayexpress

Analysis of miRNA pattern in mesenchymal stem/stromal cells derived from amniotic fluid (AF-MSCs) versus differentiated AF-MSCs into Adipocyte-Like cells (AL).

Project description:Identification of the expression pattern of miRNAs of AF-MSCs compared with differentiated AF-MSCs into adipocyte-like cells (AL cells). Significantly, the miRNAs that were found to be more than 2 fold up- or down-regulated on one or more slides were considered as differentially expressed candidates. The miRNA profile revealed 13 differentially expressed miRNAs between AF-MSCs and AL cells. MiR-26a was identified in high expression levels in AL cells indicating a critical role in the process of adipogenesis.

2017-02-01 | GSE86388 | GEO

Expression profiles of microRNA in bovine raw milk exosome and supernatant without exosome [mRNA array]

Project description:We have reported that microRNAs are present in human, bovine, and rat milk whey. Milk whey miRNAs were resistant to acidic condition and to RNase. Thus, milk miRNAs were thought to be present packaged into membrane vesicles like exosome. However, body fluid miRNAs have been reported that there are in different forms. To clarify which miRNAs species are exist in exosome and which species are exist in another form, we used bovine raw milk and purified total RNA from exosome fraction and ultracentrifugated supernatant fraction, and analyzed by miRNA microarray.

2015-03-09 | GSE61977 | GEO

Expression profiles of microRNA in bovine raw milk exosome and supernatant without exosome [miRNA array]

2015-03-09 | GSE61976 | GEO

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