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The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis [ATAC-seq]

ABSTRACT: The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis [ATAC-seq]

PROVIDER: PRJNA752582 | ENA |

REPOSITORIES: ENA

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The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis.

Project description:The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis.

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The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis [RNA-seq]

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Project description:The purpose of this study was to decipher the molecular function of ARID3A. We leveraged gene expression (RNA-Seq) and chromatin profiling (ATAC-Seq and CUT&RUN) to evaluate gene expression changes upon restoring Arid3a expression in the context of the Gata1s mutation and miR-125b overexpression

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The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis.

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-20 | GSE181570 | GEO

Chromosome 21-encoded miR-125b cooperates with GATA1s in trisomy 21-associated megakaryoblastic leukemia by targeting the megakaryocytic transcription factor ARID3A III

Project description:The purpose of this study was to decipher the gene expression changes in the ML-DS cell line CMK upon overexpression of ARID3A. For that, we used a doxycycline-inducible gene expression system to overexpress ARID3A

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Chromosome 21-encoded miR-125b cooperates with GATA1s in trisomy 21-associated megakaryoblastic leukemia by targeting the megakaryocytic transcription factor ARID3A I

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CMK LC-MS/MS after CoIP of ARID3A

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