Project description:We report the expression profiling of lung adenocarcinoma tumors arising from genetically engineered mice with activation of KRAS(K) and loss of either SMARCA4 (S), p53(P) or both.

2018-06-17 | GSE94927 | GEO

Genetically engineered endothelial niche induces vascularization in human kidney organoids

Project description:Here we developed a method to incorporate a genetically engineered endothelial niche into an established protocol for generating human kidney organoids.

2023-05-22 | GSE232767 | GEO

Modeling melanoma resistance in a genetically engineered mouse model

Project description:Modeling melanoma resistance in a genetically engineered mouse model

| PRJNA650202 | ENA

Multi-omics characterization of MEK inhibitor resistant pancreatic cancer based on a genetically engineered mouse model-derived in vitro system

Project description:Tumor heterogeneity and therapy resistance are hallmarks of pancreatic ductal adenocarcinoma (PDAC). Emerging evidence supports treatment-induced resistance to be a multifactorial process mediated by cellular plasticity involving epigenetic regulation. Here, we used a multi-omics approach to analyze in detail molecular mechanisms underlying MEK inhibitor (MEKi) resistance. Therefore, we characterized different cell stages (parental, MEKi resistant, reverted after different passages of drug withdrawal) in primary cell lines derived from a genetic PDAC mouse model, thereby minimizing inter-individual heterogeneity that could distort genome-wide analyses.

2024-01-29 | GSE146348 | GEO

Human engineered meniscus transcriptome after short-term combined hypoxia and dynamic compression

Project description:Human engineered meniscus transcriptome after short-term combined hypoxia and dynamic compression

| PRJNA702277 | ENA

Expression profiles of genetically engineered mouse model tumors (GNA11 Q209L and GNA11 Q209L Bap1 KO)

Project description:RNA-seq of end-point tumors harvested from genetically engineered mouse melanoma model

2018-01-31 | GSE97223 | GEO