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A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells

ABSTRACT: A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells

PROVIDER: PRJNA752883 | ENA |

REPOSITORIES: ENA

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A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells

Project description:We employed RNA-Seq to identify ZCF8-dependent and ZCF8-indepenent transcriptional changes in Candida albicans cells treated with nigericin.

2021-08-15 | GSE181655 | GEO

A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [ChIP-seq]

Project description:We employed ChIP-Seq to identiy direct targets of regulation of the Candida albicans transcription regulator Zcf8p.

2021-08-15 | GSE181652 | GEO

A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [RNA-seq]

Project description:We employed RNA-Seq to identify targets of regulation of the transcription regualtor ZCF8 in nitrogen-starved Candida albicans cells.

2021-08-15 | GSE181653 | GEO

A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [RNA-seq]

Project description:A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [RNA-seq]

| PRJNA752882 | ENA

A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [ChIP-seq]

Project description:A fungal transcription regulator of vacuolar functions modulates Candida albicans interactions with host epithelial cells [ChIP-seq]

| PRJNA752881 | ENA

A Fungal Transcription Regulator of Vacuolar Function Modulates Candida albicans Interactions with Host Epithelial Cells.

Project description: Not available

| S-EPMC8593675 | biostudies-literature

Manganese homeostasis modulates fungal virulence and stress tolerance in Candida albicans

Project description:As transition metal availability is very limited inside the human host, fungal pathogens have evolved sophisticated mechanisms to uptake and utilize these micronutrients at the infection interface. While considerable attention was turned into iron, copper and zinc acquisition mechanisms and their importance in fungal fitness, less was done regarding either the role of Mn in infectious processes or the cellular mechanism by which fungal cells achieve their Mn-homeostasis. Here, we undertook a transcriptional profiling of the pathogenic fungus Candida albicans experiencing both Mn starvation and excess to comprehensibly capture biological processes that are modulated by Mn. We uncovered that Mn scarcity influence diverse biological processes associated with fungal fitness including morphogenetic switch, invasion of host cells and antifungal sensitivity. We also uncovered that Mn levels influence the abundance of iron and zinc emphasizing the complex crosstalk between ions metals. Deletion of SMF12, a member of Mn Nramp transporters confirmed its contribution to Mn uptake. In accordance with the RNA-seq data, smf12 was unable to form hyphae and damage host cells, and exhibited sensitivity to azole antifungals. We also found that unfolded protein response (UPR), likely activated by decreased glycosylation under Mn limitation, was essential to promote C. albicans growth. RNA-seq profiling of cells exposed to Mn excess uncovered that the UPR signaling was also essential to bypass Mn toxicity. Collectively, this study underscores the importance of Mn homeostasis in fungal virulence, and comprehensively provides a transcriptional portrait of biological functions that are modulated by Mn in a fungal pathogen.

2024-02-13 | GSE245114 | GEO

Transcriptional profiling of orf19.5100/MLT1 ABC transporter knockout in Candida albicans

Project description:Recent reports have been suggested involvement of ABC transporters in various physiological roles.To get better insight about possible involvement of vacuolar ABC transporter MLT1/orf19.5100 in different physiological roles transcriptional profiling have been peformed and compared between WT(SC5314) Candida albicans cells vs putative orf19.5100 knockout cells after 6hrs growth of culture.The assay as peformed in biological duplicate sample. Agilent one-color experiment,Organism: Candida albicans ,Custom Agilent Candida albicans 8x15k Microarray Gene expression (AMADID: 026377) designed by Genotypic Technology Private Limited , Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442)

2016-07-25 | E-GEOD-70341 | biostudies-arrayexpress

Identification of plant vacuolar transporters mediating phosphate storage

Project description:Plant vacuoles serve as the primary intracellular compartments for inorganic phosphate (Pi) storage. Passage of Pi across vacuolar membranes plays a critical role in buffering the cytoplasmic Pi level against fluctuations of external Pi and metabolic activities. Here we demonstrate that the SPX-MFS proteins, designated as Phosphate Transporter 5 family (PHT5), also named Vacuolar Phosphate Transporter (VPT), function as vacuolar Pi transporters. Based on 31P-magnetic resonance spectroscopy analysis, Arabidopsis pht5;1 loss-of-function mutants accumulate less Pi and exhibit a lower vacuolar-to-cytoplasmic Pi ratio than controls. Conversely, overexpression of PHT5 leads to massive Pi sequestration into vacuoles and altered regulation of Pi starvation-responsive genes. Furthermore, we show that heterologous expression of OsSPX-MFS1, the rice PHT5 homolog, mediates Pi influx to yeast vacuoles. Our findings uncover a group of Pi transporters in vacuolar membranes that regulate the cytoplasmic Pi homeostasis required for the fitness of plant growth. 10-day seedlings grown on Pi-sufficient medium or followed by 1-day or 3-day Pi starvation, shoot RNA and root RNA were extracted separately

2016-03-28 | E-GEOD-74856 | biostudies-arrayexpress

Transcriptional profiling of orf19.5100/MLT1 ABC transporter knockout in Candida albicans

2016-07-25 | GSE70341 | GEO

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