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Using RNA-Seq to investigate immune-metabolism features in immunocompromised patients with sepsis

ABSTRACT: Using RNA-Seq to investigate immune-metabolism features in immunocompromised patients with sepsis

PROVIDER: PRJNA756565 | ENA |

REPOSITORIES: ENA

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Using RNA-Seq to investigate immune-metabolism features in immunocompromised patients with sepsis

Project description:Sepsis is life-threatening and leads to complex inflammation in immunocompromised subjects, including patients with cancer, those receiving immunosuppressants for autoimmune diseases and organ transplant recipients. Increasing evidence have shown that RNA-Sequencing (RNA-Seq) can be used to define subendotype in patients with sepsis; therefore, we aim to use RNA-Seq to identify transcriptomic features among immunocompromised patients with sepsis.

2021-08-23 | GSE182522 | GEO

Using RNA-Seq to Investigate Immune-Metabolism Features in Immunocompromised Patients With Sepsis.

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Whole transcriptome analysis of critically ill elderly patients with sepsis

Project description:Sepsis is a frequent complication in critically ill patients and highly heterogeneous that is associated with high morbidity and mortality rates, especially in the elderly population. Utilizing RNA-Sequencing (RNA-Seq) to analysis biological pathways is widely used in clinical and molecular genetics studies, but in elderly patients with sepsis are still lacking. Hence, we aim to investigate the mortality-relevant biological features and transcriptomic features in elderly patients who were admitted to intensive care unit (ICU) for sepsis.

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Polymorphonuclear cells show features of dysfunctional activation during fatal sepsis

Project description:Polymorphonuclear cells show features of dysfunctional activation during fatal sepsis

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Polymorphonuclear cells show features of dysfunctional activation during fatal sepsis

Project description:Sepsis and septic shock remain leading causes of morbidity and mortality for patients in Intensive care unit. In their early phase, immune cells produce various cytokines which lead to the prompt activation of the immune system. Polymorphonuclear leukocytes (PMNs) respond to different signals producing inflammatory factors and executing their antibacterial mechanisms, resulting in the engulfment and elimination of invading pathogens. However, long-term activation caused by various inflammatory signals produced during sepsis progression, can lead to the alteration of PMN signaling and subsequent defects in their functionality. Here we analyzed the PMNs samples from 34 patients in septic shock, we focused on PMNs gene expression and proteome changes caused by septic shock. We reveal that, compared to those of patients who survived, PMNs from patients who had a fulminant outcome were characterized by a dysfunctional hyper-activation, showing an altered metabolism, higher longevity and recent exit from cell cycle. We believe that this multi-omics approach, although limited, served to pinpoint the alterations in PMNs’ functionality, which may be reverted by targeted treatments.

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Using ATAC-Seq to investigate the impact of vaccination on the epigenome

Project description:We used a mouse model to investigate whether live (BCG) and non-live (DTPw) vaccines differentially reprogram trained immune responses and to investigate whether immunisation with DTPw altered susceptibility to sepsis. We found that compared to BCG-immunised mice, DTPw immunisation led to altered monocyte and dendritic cell (DC) cytokine responses to subsequent secondary stimuli, as well as genome-wide changes to chromatin accessibility in DCs. These effects were evident months after immunisation and are consistent with different programs of trained immunity being induced by live versus non-live vaccines.

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Transcriptomic characteristics and impaired immune function of patients with sepsis

Project description:Sepsis is a life-threatening condition caused by a dysregulated host response to infection.Although our understanding in the pathophysiological features of sepsis has increased significantly during the past decades, there is still lack of mechanism of sepis.Neutrophils are important regulators against invading pathogens, and their role during sepsis has been studied extensively. However, whether neutrophils could inhibit the immune response of CD8+T cells and the mechanism is unkown in sepsis.

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Altered gene expression in plasma of patients with pneumonia-induced sepsis compared to pneumonia without sepsis and healthy people

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Project description:Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis

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Gene expression data from compstatin treated E.coli-Induced primate sepsis model

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2013-08-31 | E-GEOD-23590 | biostudies-arrayexpress

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