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Circulating circRNA signature in pregnancies with gestational diabetes mellitus

ABSTRACT: Circulating circRNA signature in pregnancies with gestational diabetes mellitus

PROVIDER: PRJNA757644 | ENA |

REPOSITORIES: ENA

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Circulating circRNA signature in pregnancies with gestational diabetes mellitus

Project description:Circular RNA can regulate blood glucose levels by targeting mRNA expression, but the role of circRNA in GDM is still unknown. Therefore, a joint microarray analysis of circRNAs and their targeting mRNAs using the peripheral blood of GDM patients and healthy pregnant women was carried out for the first time. In our study, high-throughput microarray sequencing technique was used to analyze the expression profile of circRNA and transcripts mRNA in the peripheral blood of GDM patients, in order to comprehensively evaluate the role of circRNAs targets and their parents genes in the signal pathways related to the pathogenesis of GDM. Some of the discovered circRNAs and their linear transcript mRNAs related to T cell receptor signaling pathway were further verified in larger samples by droplet digital PCR(ddPCR) and quantitative real-time PCR(qRT-PCR), respectively. The verification results confirmed the initial microarray results.

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Circulating exosomal miRNA signature in pregnancies with gestational diabetes mellitus across gestation

Project description:Circulating exosomal miRNA signature in pregnancies with gestational diabetes mellitus across gestation

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2021-06-23 | GSE122086 | GEO

Circulating exosomal miRNA signature in pregnancies with gestational diabetes mellitus across gestation

Project description:The aim of this study was to establish the exosomal miRNA profile across gestation in normal and GDM pregnancies and to determine the signaling pathways associated with the changes in the miRNA profile in GDM.

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2021-12-28 | PXD030656 | iProX

Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies

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Serum exosomal miRNA profile in pregnancies with gestational diabetes based on pancreatic β-cell function

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Transcriptional profile of peripheral blood mononuclear cells from Gestational Diabetes Mellitus Patients

Project description:The oligo microarray were used to determine gene expression profile of PBMC from gestational diabetes mellitus (GDM) patients.

2012-08-25 | E-MEXP-3349 | biostudies-arrayexpress

Transcriptional profiles of microRNAs from peripheral blood mononuclear cells of gestational diabetes mellitus patients

Project description:The oligo micoarrays were used to determine gene expression profiles of peripheral blood mononuclear cells from gestational diabetes mellitus (GDM) patients.

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