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Global gene expression profiling of M. tuberculosis H37Rv and the isogenic regX3-inactivated mutant (DregX3) grown in phosphate enriched or phosphate-limited medium

ABSTRACT: Global gene expression profiling of M. tuberculosis H37Rv and the isogenic regX3-inactivated mutant (DregX3) grown in phosphate enriched or phosphate-limited medium

PROVIDER: PRJNA757706 | ENA |

REPOSITORIES: ENA

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Global gene expression profiling of M. tuberculosis H37Rv and the isogenic regX3-inactivated mutant (DregX3) grown in phosphate enriched or phosphate-limited medium

Project description:In order to understand the repertoire of genes regulated by RegX3, we performed microarray analysis of gene expression in M. tuberculosis (WT) or DregX3 grown in phosphate-enriched or phosphate limited medium. The differentially regulated genes provide insight into the role of RegX3 in gene regulation in Mtb.

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Project description:We used the previously designed oligonucleotide microarrays (BM-CM-<rgmann et al., 2007, Environmental Microbiology, 9: 2742-2755) to detect the mRNA transcripts of R. pomeroyi DSS-3 when the cells were cultured under steady-state conditions limited with ammonium (NH4Cl, 0.26 mM) but with an excess of D-ribose-5-phosphate (C5H9Na2O8P*2H2O, 0.5 mM), methylphosphonic acid (CH5PO3, 0.5 mM), or potassium phosphate (KH2PO4, 0.5 mM), or during ammonium excess (NH4Cl, 2.8 mM) but were limited with potassium phosphate (KH2PO4, 9.2 M-NM-<M). A total of 13 microarray hybridizations were performed: three biological replicates each from ribose phosphate, methylphosphonate, or potassium phosphate excess growth regimes, three biological replicates from potassium phosphate limited growth regime, and one technical replicate for the potassium phosphate excess growth regime. Data for the technical replicates were averaged and combined, resulted in a total of 12 samples.

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