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Transcriptional effects of HSV-1-ICP0 and Ad5-E4ORF3 expression in BLaER1 monocytes [Virulence factors]

ABSTRACT: Transcriptional effects of HSV-1-ICP0 and Ad5-E4ORF3 expression in BLaER1 monocytes [Virulence factors]

PROVIDER: PRJNA757714 | ENA |

REPOSITORIES: ENA

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Transcriptional effects of HSV-1-ICP0 and Ad5-E4ORF3 expression in BLaER1 monocytes [Virulence factors]

Project description:We have identified that the viral virulence factors ICP0 from HSV-1 and E4ORF3 from Adenovirus5 can activate the MORC3 pathway of innate immune sensing. To study the global transcriptional effects of virulence factor sensing, we overexpressed mCherry or these virulence factors from a doxycycline-inducible lentiviral construct in BLaER1 monocytes of various genotypes and performed RNA-seq.

2021-11-01 | GSE182754 | GEO

Transcriptional profile of MORC3 deficient BLaER1 monocytes [KO]

Project description:Transcriptional profile of MORC3 deficient BLaER1 monocytes [KO]

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ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]

Project description:ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]

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Transcriptional profile of MRE deficient BLaER1 monocytes [RNA MRE]

Project description:Transcriptional profile of MRE deficient BLaER1 monocytes [RNA MRE]

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Transcriptional profile of MORC3 deficient BLaER1 monocytes [KO]

Project description:We have identified MORC3 as a negative regulator of Type I Interferon (IFN), whose absence induces IFN and interferon-stimulated genes (ISGs). To study the global transcriptional effects of loss of MORC3, we deleted MORC3 in WT, IFNAR1–/– IFNAR2–/– and IFNB1–/– BLaER1 monocytes and performed RNA-seq.

2021-11-01 | GSE182755 | GEO

Transcriptional profile of MRE deficient BLaER1 monocytes [RNA MRE]

Project description:We have identified a MORC3-regulated DNA element (MRE) that regulates the activation of IFNB1 upon loss of MORC3. To study the global transcriptional effects of the MRE, we deleted the MRE in STAT1–/– STAT2–/– and STAT1–/– STAT2–/– MORC3–/– BLaER1 monocytes and performed RNA-seq.

2021-11-01 | GSE182753 | GEO

ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]

Project description:We have identified MORC3 as a negative regulator of Type I Interferon (IFN), whose absence induces IFN and interferon-stimulated genes (ISGs). To study the global effects of MORC3 on DNA accessibility, we deleted MORC3 in IFNAR1-/- IFNAR2-/- BLaER1 monocytes and performed ATAC-seq.

2021-11-01 | GSE182752 | GEO

The comparsion of gene expression in ALVAC- and Ad5-infected human monocyte-derived dendritic cells

Project description:Analysis of the effects of different vaccine viral vectors on gene expression in human monocyte-derived dendritic cells (MDDCs), which were generated from isolated monocytes from 3 different donors. The goal in this study was to find the difference of gene expression in human MDDCs upon ALVAC and Ad5 vrial vectors infection.

2017-09-27 | GSE103204 | GEO

Gene expression profiles of human Ad5- and CMV-specific CD4 T cells

Project description:Analysis of global gene expression profiles of FACS-sorted, human Ad5- and CMV-specific CD4 T cells from the same PBMC sample of healthy donros, using affymetrix Human Gene 2.0ST Gene-Chips; The analysis show that Ad5- and CMV-specific CD4 T cells demonstrate differential gene expression profiles even though the cells are from the same PBMC

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Stacking the odds: multiple sites for HSV-1 latency

Project description:investigated the possible contribution of various cells (i.e., B cells, DCs, fibroblasts, glial cells, ILCs, macrophages, microglia, monocytes, NK cells, neurons, neutrophils, and T cells) isolated from TG of latently infected mice to HSV-1 latency

2023-02-22 | GSE225839 | GEO

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