Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

ABSTRACT: The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

PROVIDER: PRJNA762051 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

Project description:RNA-binding proteins and messenger RNAs assemble into ribonucleoprotein granules that regulate mRNA trafficking, local translation, and turnover. The dysregulation of RNA-protein condensation disturbs synaptic plasticity and neuron survival, and has been widely associated with human neurological disease. Neuronal granules are thought to condense around particular proteins that dictate the identity and composition of each granule type. Here, we show in Drosophila that a previously uncharacterized long non-coding RNA, mimi, is required to scaffold large neuronal granules in the adult nervous system. Neuronal ELAV-like proteins directly bind mimi and mediate granule assembly, while Staufen maintains condensate integrity. mimi granules contain mRNAs and proteins involved in synaptic processes; granule loss in mimi mutant flies impairs nervous system maturity, neuropeptide-mediated signaling and causes phenotypes of neurodegeneration. Our work reports the first architectural RNA for a neuronal granule and provides a handle to interrogate functions of a condensate independently from those of its constituent proteins.

2022-06-15 | GSE183812 | GEO

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

2022-06-15 | GSE183815 | GEO

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

2022-06-15 | GSE183814 | GEO

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

2022-06-15 | GSE183813 | GEO

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

Project description:The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

| PRJNA762039 | ENA

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

Project description:The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

| PRJNA762048 | ENA

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

Project description:The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

| PRJNA762049 | ENA

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

Project description:The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

| PRJNA762050 | ENA

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-15 | GSE183816 | GEO

Proteomic Analysis of fly brain cytoplasmic RNP granules containing the lncRNA mimi

Project description:In neurons, mRNAs and associated RNA-binding proteins assemble into ribonucleoprotein (RNP) granules essential to regulate mRNA trafficking, local translation, and turnover. Dysregulation of RNA-protein condensation can disturb synaptic plasticity. We report that the novel lncRNA mimi is a constitutive and essential component of large cytoplasmic condensates (RNP granules) in fly neurons that are biochemically enriched by differential centrifugation. Here, employing relative iBAQ quantification we carry out a differential proteomic analysis of cytoplasmic RNP granules in wild-type versus delta-mimi mutant fly brains. Brain lysates from wild-type and mutant flies serve as a general proteome input control.

2022-10-12 | PXD034453 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data