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Specification of human immune cell epigenetic identity by combinations of transcription factors (MethylationEPIC)

ABSTRACT: Specification of human immune cell epigenetic identity by combinations of transcription factors (MethylationEPIC)

PROVIDER: PRJNA763867 | ENA |

REPOSITORIES: ENA

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Specification of human immune cell epigenetic identity by combinations of transcription factors

Project description:Specification of human immune cell epigenetic identity by combinations of transcription factors

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Specification of human immune cell epigenetic identity by combinations of transcription factors (MethylationEPIC)

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Pluripotency Factors Regulate Definitive Endoderm Specification through Eomesodermin

Project description:Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective towards the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells (hESCs) to study specification of definitive endoderm in vitro. Using a combination of whole genome expression and ChIP-seq analyses, we established a hierarchy of transcription factors regulating endoderm specification. Importantly, pluripotency factors, namely NANOG, OCT4 and SOX2 have an essential function in this network by actively directing differentiation. Indeed, these transcription factors control the expression of EOMES, which marks the onset of endoderm specification. In turn, EOMES interacts with SMAD2/3 to initiate the transcriptional network governing endoderm formation. Together, these results provide for the first time a comprehensive molecular model connecting the transition from pluripotency to endoderm specification during mammalian development. ChIP-Seq of Eomesodermin binding in human embyonic stem cells, differentiated towards an endodermal fate for 48h in chemically-defined culture media. Includes an input DNA control. Supplementary file GSE26097_README.txt contains descriptions of the raw data files and processed data files.

2011-01-25 | E-GEOD-26097 | biostudies-arrayexpress

Pluripotency Factors Regulate Definitive Endoderm Specification through Eomesodermin

2011-01-25 | GSE26097 | GEO

Methylation arrays (MethylationEPIC) of peripheral blood of individuals with evolving dementia

Project description:DNA methylation changes have been associated to dementia and cognitive decline. However, it is not clear if these changes arise before or during the onset of the pathologies. Here, using Illumina's MethylationEPIC array technology, we have profiled the methylomes of elderly, cognitively healthy individuals which go on to develop dementia or stay cognitively healthy. The subjects are profiled at a pre-diagnosis stage and at 4 year follow-up post-diagnosis.

2022-04-25 | E-MTAB-10600 | biostudies-arrayexpress

Methylation arrays (MethylationEPIC) of whole blood of individuals with type 1 diabetes

Project description:Type 1 diabetes (1a) diabetes is an autoimmune disease in which both environmental and genetic factors play a role. Epigenetic marks such as DNA methylation, being molecular links between the environment and the genome function, are sound candidates for the explanation of part of the aetiology and mechanisms of the disease. Here, the methylomes of the whole blood of 18 adult individuals with T1D were profiled using Illumina's MethylationEPIC array technology.

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