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Anthrax toxins regulate pain signaling and can deliver molecular cargoes to Antxr2+ DRG sensory neurons

ABSTRACT: Anthrax toxins regulate pain signaling and can deliver molecular cargoes to Antxr2+ DRG sensory neurons

PROVIDER: PRJNA765371 | ENA |

REPOSITORIES: ENA

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Anthrax toxins regulate pain signaling and can deliver molecular cargoes to Antxr2+ DRG sensory neurons

Project description:We found that intrathecal injection of anthrax edema toxin (ET), causes analgesia in adult B6J mice. In order to determine if DRG neuron transcriptional responses play a role in pain blockade, we performed a bulk RNA-seq experiment on dissected mouse DRG neurons. We report that anthrax edema toxin causes transcriptional responses in DRG neurons 2h after in vivo administration

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Multiple stages of evolutionary change in anthrax toxin receptor expression in humans

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Expression data from pain model: rat L5 sensory ganglia after local inflammation

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DRG from CCI and Seltzer models of neuropathic pain and sham operated animals

Project description:L5 DRG samples from CCI, Seltzer and sham models collected at 14, 21 and 50 days after surgery from ipsilateral hind limb. Note that all replicates are techincal, i.e., there were no biological replicates in this study as samples were pooled for each group Keywords: ordered

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Expression data from pain model: rat L5 sensory ganglia after local inflammation

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scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of PirtEGFPf mice in neuropathic pain condition

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