Genomics

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Transcriptomic profiles revealed down regulation of low-density lipoprotein particle receptor activity pathway in survived from severe COVID-19-19.


ABSTRACT: Transcriptomic profiles revealed down regulation of low-density lipoprotein particle receptor activity pathway in survived from severe COVID-19-19.

PROVIDER: PRJNA771040 | ENA |

REPOSITORIES: ENA

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Transcriptomic Profiles Reveal Downregulation of Low-Density Lipoprotein Particle Receptor Pathway Activity in Patients Surviving Severe COVID-19.

Vlasov Ivan I   Panteleeva Alexandra A   Usenko Tatiana T   Nikolaev Mikhael M   Izumchenko Artem A   Gavrilova Elena E   Shlyk Irina I   Miroshnikova Valentina V   Shadrina Maria M   Polushin Yurii Y   Pchelina Sofya S   Slonimsky Petr P  

Cells 20211210 12


To assess the biology of the lethal endpoint in patients with SARS-CoV-2 infection, we compared the transcriptional response to the virus in patients who survived or died during severe COVID-19. We applied gene expression profiling to generate transcriptional signatures for peripheral blood mononuclear cells (PBMCs) from patients with SARS-CoV-2 infection at the time when they were placed in the Intensive Care Unit of the Pavlov First State Medical University of St. Petersburg (Russia). Three di  ...[more]

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