Project description:One of the most distinct features of Pseudoalteromonas sp. SCSIO 11900 is its ability to form a very robust pellicle than most Pseudoalteromonas strains. Thus we want to identify the genes essential for the pellicle formation of SCSIO 11900. We compared transcriptom profiles of planktonic cells, initial pellicle and mature pellicle of coral Pseudoalteromonas sp. SCSIO 11900 and revealed that some unique genes from horizontal gene transfer is involved in the pellicle formation of SCSIO 11900.

2017-04-04 | GSE97322 | GEO

Kiloniella spongiae strain:MEBiC09566

Project description:Kiloniella spongiae Genome sequencing

| PRJNA279544 | ENA

Transcriptome profiling of planktonic stage to biofilm stage of deep sea bacterium Pseudoalteromonas sp. SM9913

Project description:We compared genetic profiles of planktonic stage to biofilm stage of deep sea bacterium Pseudoalteromonas sp. SM9913 and revealed genetic features during switch from planktonic to pellicle stage in Pseudoalteromonas sp. SM9913. mRNA profiles of Pseudoalteromonas sp. SM9913 planktonic cells, initial pellicle cells and mature pellicle cells were generated by Illumina Hiseq2000.

2015-11-03 | E-GEOD-74569 | biostudies-arrayexpress

Parashewanella spongiae

Project description:Parashewanella spongiae overview

| PRJNA526959 | ENA

Liver transcriptome analysis after DF-006 treatment in an HBV mouse model

Project description:A new chemical entity, DF-006, has been shown to suppress HBV replication in an AAV-HBV mouse model. DF-006 activates NF-kB signaling. In order to elucidate the mechanism of action of DF-006, specifically the genes expression stimulated in the liver that mediated its anti-HBV efficacy, we perform deep sequencing of RNA samples taken from AAV-HBV mice 4 hours after 10 μg/kg DF-006 oral administration or vehicle control. AAV-HBV mouse models were established by injecting male C57B6/J mice with 1011 vg/mouse AAV-HBV (genotype D, serotype ayw, GenBank accession number: KX449554). Dosing with DF-006 resulted in a statistically significant increase of gene expression for 1,685 genes in the liver. We performed an over-representation analysis for Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and found 53 pathways were significantly enriched. The top 10 pathways included those that involved viral infection (e.g., herpes, influenza, Epstein-Barr, hepatitis B, measles) and those that involved host innate responses (TNF, osteoclast differentiation, NF-κB, toll-like receptor, RIG-I -like receptor). qPCR analysis confirmed genes that are directly or indirectly induced through NF-kB pathway and are reported before to play a role in HBV suppression.

2022-08-11 | GSE210856 | GEO

Mycetocola spongiae strain:MSC19

Project description:Mycetocola spongiae strain:MSC19 Genome sequencing

| PRJNA746413 | ENA

Parashewanella spongiae strain:HJ039

Project description:Parashewanella spongiae strain:HJ039 Genome sequencing

| PRJNA526823 | ENA