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Comprehensive transcriptome analysis of heart tissues in the sugen/hypoxia rats with/without treatment of chrysin

ABSTRACT: Comprehensive transcriptome analysis of heart tissues in the sugen/hypoxia rats with/without treatment of chrysin

PROVIDER: PRJNA777235 | ENA |

REPOSITORIES: ENA

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Comprehensive transcriptome analysis of heart tissues in the sugen/hypoxia rats with/without treatment of chrysin

Project description:Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remodeling leading to increased pulmonary vascular resistance and right ventricular (RV) hypertrophy, resulting in RV failure. RV dysfunction is a complex process that leads to cardiomyocyte hypertrophy, fibrosis, inflammation, angiogenesis, and metabolic changes. In patient with PAH, the adaptation of the RV to high pulmonary arterial pressures is the most important determinant of prognosis. However, the underlying molecular mechanism of adverse RV remodeling and dysfunction is poorly understood, and there are no currently approved therapies that improve RV function. Chrysin (5,7-dihydroxyflavone) is a phytochemical, which is a flavonoid widely present in plant sources. In various experimental models chrysin has shown to exert cardio-protective effects through its antioxidant and anti-inflammatory effects. In this study, we performed a comprehensive analysis of gene expression changes in heart tissues of rats under hypoxic conditions with chrysin treatment using RNA sequencing (RNA-seq).

2022-02-15 | GSE186989 | GEO

Comprehensive transcriptome analysis of lung tissues in the sugen/hypoxia rats with/without treatment of chrysin or trimetazidine

Project description:Pulmonary arterial hypertension (PAH) is a debilitating progressive disease characterized by high blood pressure in the pulmonary artery. Chrysin (5,7-dihydroxyflavone) is a phytochemical, which is a flavonoid widely present in plant sources. It is known that right ventricular dysfunction is the worst mortality predictor in patient with PAH. Recent studies have shown that chrysin improves hemodynamic parameters including right ventricular pressure, right ventricular hypertrophy, and pulmonary vascular remodeling in a rat model of chronic hypoxia-induced pulmonary hypertension. On the other hand, trimetazidine (TMZ) is an anti-ischemic agent widely used in the treatment of coronary artery disease. It has been reported that trimetazidine therapy for 3 months on top of standard PAH regime significantly improve right ventricular ejection fraction and functional capacity in patient with PAH. However, the effects of chrysin or trimetazidine on gene expression in lung of patient with PAH. Here, we performed that a comprehensive analysis of gene expression changes in lung tissues of sugen-received rats under hypoxic conditions, which is a model of PAH with chrysin or trimetazidine treatment using RNA sequencing (RNA-seq).

2024-05-16 | GSE186996 | GEO

The transcriptome sequencing of Chrysin treated Scc9 Extracellular vesicles

Project description:EVs-Chrysin(Chrysin-treated SCC9) were isolated from SCC9 cells that were treated with chrysin. To improve the therapeutic effect, AuNPs were carried by EVs-Chrysin (Au-EVs). Compared to BGC823 and HCC-LM3 cells, the uptake of Au-EVs were specific in SCC9 cells. Moreover, Au-EVs combined with NIR enhanced cell apoptosis in TSCC cells. To confirm the role of miRNAs in cell apoptosis, the differentially expressed miRNAs between EVs-Con and EVs-Chrysin were screened by RNA-seq.

2021-10-12 | GSE185562 | GEO

The RNA-seq result of GC cells which were treated with chrysin

Project description:Chrysin has been reported to have anticancer effect. We used 40μM chrysin to treat SGC7901 cells for 48h, then sequenced their RNA, analyzed the differentially expressed genes before and after treatment, screened out the anticancer target of chrysin, and then carried on the next analysis

2021-08-19 | GSE181492 | GEO

Transcriptome analysis following Apigenin and Chrysin treatment of Mouse Embryonic Fibroblasts

Project description:There is no known single therapeutic drug for treating hypercholesterolemia that comes with negligible systemic side effects. In the current study, using next generation RNA sequencing approach in mouse embryonic fibroblasts we discovered that two structurally related flavonoid compounds, Apigenin and Chrysin exhibited moderate blocking ability of multiple transcripts that regulate rate limiting enzymes in the cholesterol biosynthetic pathway. The observed decrease in cholesterol biosynthesis pathway correlated well with an increase in transcripts involved in generation and trafficking of ketone bodies as evident by the upregulation of Bdh1 and Slc16a6 transcripts. Impact statement - The hypocholesterolemic potential of Apigenin and Chrysin at higher concentrations along with their ability to generate ketogenic substrate especially during embryonic stage is useful or detrimental for embryonic health is not clear and still debatable. Our findings will set the stage for translating this information to whole animal and clinical studies that could shed light to the existing information regarding safe use of Apigenin and Chrysin, specifically to embryonic health.

2021-08-09 | GSE155852 | GEO

RNA-seq analysis of A549 cells treated with chrysin or nifurtimox

Project description:The influences of 40 hours treatment of 30 μM chrysin (CAS No: 480-40-0) or 30 μM nifurtimox (CAS No: 23256-30-6) on A549 cell gene expression profile were examined by RNA sequencing.

2022-03-01 | GSE193541 | GEO

Zebrafish Hypoxia study Heart array

Project description:Gene expression profile of the response to chronic constant hypoxia in the heart of adult zebrafish Keywords: Adaptive response to chronic constant hypoxia in the heart

2006-07-06 | GSE4989 | GEO

The transcriptome sequencing of Chrysin treated Scc9 Extracellular vesicles

Project description:The transcriptome sequencing of Chrysin treated Scc9 Extracellular vesicles

| PRJNA769670 | ENA

Expression data of lung tissues of rats exposed to chronic hypoxia

Project description:Expression data of lung tissues of rats exposed to chronic hypoxia

| PRJNA527784 | ENA

Heart fibroblasts from Siah-knockout mice in hypoxia

Project description:Heart fibroblasts from wildtype mice and Siah2-/- knockout mice were isolated and cultured. The cells were either left untreated or incubated for 6 hs under hypoxic conditions. One experiment consists of wildtype cells (normoxia/hypoxia) and Siah2 knockout cells (normoxia/hypoxia) = 4 samples. To allow statistical analysis of the data set the experiment was repeated once under identical conditions.

2021-07-01 | GSE154667 | GEO

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