Project description:Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (Oophaga sylvatica) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within four days, and dietary alkaloid exposure modified protein abundance in the intestines, liver, and skin. Many proteins that increased in abundance with toxin accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with toxin accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues
Project description:Phylogenomic analysis of a rapid radiation of misfit fishes (Syngnathiformes) using ultraconserved elements
| PRJNA378844 | ENA
Project description:Phylogenomic reappraisal of the suckermouth armored catfish family Loricariidae (Teleostei: Siluriformes) using thousands of ultraconserved elements
| PRJNA496344 | ENA
Project description:Conservation and phylogenomic reconstruction of the Neotropical poison frogs (Dendrobatidae)
| PRJNA547821 | ENA
Project description:Analysis of ultraconserved elements supports African origins of narrow-mouthed frogs
| PRJNA564703 | ENA
Project description:Phylogenetic relationships of the Chagas disease vectors Triatominae using Ultraconserved Elements (Hemiptera: Reduviidae)
| PRJNA595376 | ENA
Project description:New perspectives on the evolutionary history of the catfish family Heptapteridae using genome-scale analyses ultraconserved elements (Teleostei, Siluriformes)
| PRJNA723556 | ENA
Project description:Phylogenomics of bumblebee catfishes of the family Pseudopimelodidae using ultraconserved elements (Teleostei: Siluriformes)