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Mapping translation in wild-type and METTL5 knockout (KO) mice

ABSTRACT: Mapping translation in wild-type and METTL5 knockout (KO) mice

PROVIDER: PRJNA780403 | ENA |

REPOSITORIES: ENA

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Mapping translation in wild-type and METTL5 knockout (KO) mice

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Mapping translation in wild-type and METTL5 knockout (KO) HepG2 cells

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Mapping translation in wild-type and METTL5 knockout (KO) HepG2 cells

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Mapping N6-methyladenosine (m6A) peaks in wild-type and METTL5 knockout (KO) HeLa cells

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RNA-seq and Ribo-seq of WT and METTL5 KO mECS.

Project description:Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, our mechanistic understanding of the enzymes catalysing these modifications, their substrates and biological functions remains vague. Here, we undertook a systematic screen to uncover new RNA methyltransferases. We demonstrate that the methyltransferase-like 5 (METTL5) protein catalyses m6A in 18S rRNA at position A1832. We report that absence of Mettl5 in mouse embryonic stem cells (mESCs) results in a changes gene expression, decrease in translation rate, spontaneous loss of pluripotency and compromised differentiation potential. Mice lacking METTL5 recapitulate symptoms of patients with METTL5 mutations, thereby providing a new mouse disease model. Overall, our work highlights the importance of m6A in rRNA in stemness, differentiation, development and diseases.

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