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Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [bulk RNA-seq]

ABSTRACT: Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [bulk RNA-seq]

PROVIDER: PRJNA782685 | ENA |

REPOSITORIES: ENA

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Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues

Project description:Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues

| PRJNA782679 | ENA

Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [bulk RNA-seq]

Project description:Vaginal tissue Tregs acquire a inflammatory cytokine-dependent, infection-specific phenotype after local infection with HSV-2

2022-04-15 | GSE189373 | GEO

Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [single-cell RNA-seq]

Project description:Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [single-cell RNA-seq]

| PRJNA782684 | ENA

Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues [single-cell RNA-seq]

Project description:Vaginal tissue Tregs acquire a inflammatory cytokine-dependent, infection-specific phenotype after local infection with HSV-2

2022-04-15 | GSE189374 | GEO

Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-15 | GSE189375 | GEO

Cohesin residency determines chromatin loop patterns

Project description:Cohesin residency determines chromatin loop patterns

| PRJNA635793 | ENA

Cohesin residency determines chromatin loop patterns

Project description:Cohesin residency determines chromatin loop patterns

| PRJNA636358 | ENA

Heme exposure induces the phenotype of Hmox1high, Marcohigh, and MHC class IIlow macrophages

Project description:Bulk RNA sequencing revealed that heme exposure induced the phenotype of Hmox1high, Marcohigh, and MHC class IIlow macrophages, demonstrating a strong expression of NRF2-regulated. However, these cells showed weak expression of the TAM marker genes Arg1 and Spp1, indicating that heme treatment alone was insufficient to induce the full heme-TAM phenotype.

2024-01-03 | GSE237238 | GEO

Electrospun scaffold micro-architecture induces an activated transcriptional phenotype within tendon fibroblasts. Bulk RNA-seq data.

Project description:Electrospun scaffold micro-architecture induces an activated transcriptional phenotype within tendon fibroblasts. Bulk RNA-seq data.

| PRJNA785809 | ENA

Distinct murine mucosal Langerhans cell subsets develop from pre-DCs and monocytes

Project description:Langerhans cells (LCs) populate the mucosal epithelium, a major entry portal for pathogens, yet their ontogeny remains unclear. In contrast to skin LCs originating from self-renewing radioresistant embryonic precursors, we found that oral mucosal LCs derive from circulating radiosensitive precursors. Mucosal LCs can be segregated into CD103+CD11blow (CD103+LCs) and CD11b+CD103- (CD11b+LCs) subsets. We further demonstrated that similar to non-lymphoid dendritic cells (DCs), CD103+LCs originate from pre-DCs, whereas CD11b+LCs differentiate from both pre-DCs and monocytic precursors. Despite this ontogenetic discrepancy between skin and mucosal LCs, transcriptomic signature and immunological function of oral LCs highly resemble those of skin LCs but not DCs. These findings, along with their epithelial position, morphology and expression of LC-associated phenotype strongly suggest that oral mucosal LCs are genuine LCs. Collectively, in a tissue-dependent manner, murine LCs differentiate from at least three distinct precursors (embryonic, pre-DCs and monocytic) in steady state The following cells were isolated from mice (2-4 replicates): Lung DCs, mucosal CD103+ LC, mucosal CD11b+ LC, Skin LC. Transcriptome analysis was performed.

2015-08-31 | E-GEOD-68789 | biostudies-arrayexpress

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