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Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer [ATAC-seq]

ABSTRACT: Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer [ATAC-seq]

PROVIDER: PRJNA787581 | ENA |

REPOSITORIES: ENA

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Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer

Project description:Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer

| PRJNA787577 | ENA

Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer [RNA-seq]

Project description:Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer [RNA-seq]

| PRJNA787582 | ENA

Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-12 | GSE190574 | GEO

Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer [ATAC-seq]

Project description:MCF-10A breast epithelial cells were exposed to fatty acids to determine if lipids engender changes in gene expression associated with malignant transformation.

2021-12-12 | GSE190573 | GEO

Lipid Metabolism (LiMe) genes and the genesis of estrogen receptor negative breast cancer [RNA-seq]

Project description:MCF-12A breast epithelial cells were exposed to fatty acids to determine if lipids engender changes in gene expression associated with malignant transformation.

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Phytoplasma-responsive small RNAs in Mexican lime trees

Project description:Background: Witches’ broom disease of Mexican lime (Citrus aurantifolia L.), which is caused by the phytoplasma “Candidatus Phytoplasma aurantifolia”, is a devastating disease that results in significant economic losses. Plants adapt to abiotic stresses by regulating gene expression at the transcriptional and post-transcriptional levels. MicroRNAs (miRNAs) are a recently identified family of molecules that regulate plant responses to environmental stresses through post-transcriptional gene silencing. Methods: Using a high-throughput approach to sequence small RNAs, we compared the expression profiles of miRNAs in healthy Mexican lime trees and in plants infected with “Ca. Phytoplasma aurantifolia”. Results: Our results demonstrated the involvement of different miRNAs in the response of Mexican lime trees to infection by “Ca. Phytoplasma aurantifolia”. We identified miRNA families that are expressed differentially upon infection with phytoplasmas. Most of the miRNAs had variants with small sequence variations (isomiRs), which are expressed differentially in response to pathogen infection. Conclusions: It is likely that the miRNAs that are expressed differentially in healthy and phytoplasma-infected Mexican lime trees are involved in coordinating the regulation of hormonal, nutritional, and stress signalling pathways, and the complex interactions between them. Future research to elucidate the roles of these miRNAs should improve our understanding of the level of diversity of specific plant responses to phytoplasmas.

2013-03-09 | GSE44279 | GEO

The application of LIMe-ID to study the impact of PRC2 perturbations on lamina assoication.

Project description:We developed and performed LIMe-ID to simultaneously measure lamina association and DNA methylation in one experimental workflow. We then conducted LIMe-ID following perturbations of PRC2 to better understand the influence of H3K27me3 on lamina association.

2022-06-17 | GSE198615 | GEO

Phytoplasma-responsive small RNAs in Mexican lime trees

Project description:Background: WitchesM-bM-^@M-^Y broom disease of Mexican lime (Citrus aurantifolia L.), which is caused by the phytoplasma M-bM-^@M-^\Candidatus Phytoplasma aurantifoliaM-bM-^@M-^], is a devastating disease that results in significant economic losses. Plants adapt to abiotic stresses by regulating gene expression at the transcriptional and post-transcriptional levels. MicroRNAs (miRNAs) are a recently identified family of molecules that regulate plant responses to environmental stresses through post-transcriptional gene silencing. Methods: Using a high-throughput approach to sequence small RNAs, we compared the expression profiles of miRNAs in healthy Mexican lime trees and in plants infected with M-bM-^@M-^\Ca. Phytoplasma aurantifoliaM-bM-^@M-^]. Results: Our results demonstrated the involvement of different miRNAs in the response of Mexican lime trees to infection by M-bM-^@M-^\Ca. Phytoplasma aurantifoliaM-bM-^@M-^]. We identified miRNA families that are expressed differentially upon infection with phytoplasmas. Most of the miRNAs had variants with small sequence variations (isomiRs), which are expressed differentially in response to pathogen infection. Conclusions: It is likely that the miRNAs that are expressed differentially in healthy and phytoplasma-infected Mexican lime trees are involved in coordinating the regulation of hormonal, nutritional, and stress signalling pathways, and the complex interactions between them. Future research to elucidate the roles of these miRNAs should improve our understanding of the level of diversity of specific plant responses to phytoplasmas. Small mRNA profiles of healthy (H) and Phytoplasma-infected Mexican lime trees were generated by deep sequencing, six replicate, using Illumina Hiseq2000

2013-03-09 | E-GEOD-44279 | biostudies-arrayexpress

Inhibition of EZH2 with GSK343 in the LIMe-Hi-C K562 clone

Project description:We characterized the the effect of EZH2 inhibition on gene expression in the LIMe-Hi-C K562 clone

2022-06-17 | GSE180229 | GEO

Estrogen signaling through Estrogen Receptor ⍺ alters lipid metabolism and promotes glomerulonephritis

Project description:Transcriptome analysis of RNA samples from glomeruli with and without functional ER⍺ duringnNephrotoxic serum-induced nephritis. There is sex bias in SLE and lupus nephritis with a 9:1 women to men ratio. Timecourse microarray analysis of glomeruli isolated from kidneys during nephrotoxic serum-induced nephritis (NTN) reveled altered expression of genes related to lipid metabolism in WT females compared to ER⍺KO females.

2017-11-03 | GSE98626 | GEO

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