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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

ABSTRACT: Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

PROVIDER: PRJNA787920 | ENA |

REPOSITORIES: ENA

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia II

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia [mouse_RNA-seq]

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia [ChIP-seq]

Project description:Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia [ChIP-seq]

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia (RNA-Seq)

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia (ChIP-Seq)

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia [mouse_RNA-seq]

Project description:Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 at MECOM drive inv(3)/t(3;3) myeloid leukemias and revealed MECOM germline mutations in patients with MECOM-associated bone marrow failure syndromes. Here we identify a novel, previously unannotated oncogenic RNA-splicing derived isoform of EVI1 which is frequently present in inv(3)/t(3;3) AML and directly contributes to leukemic transformation. Expression of this EVI1 splice variant enhanced the self-renewal of hematopoietic stem cells and introduction of mutant SF3B1 in mice bearing the humanized inv(3)(q21;26) allele hastened leukemogenesis in vivo. These data provide a mechanistic basis for the frequent co-occurrence of SF3B1 mutations as well as new insights into the pathogenesis of myeloid leukemias harboring inv(3)/t(3;3).

2022-06-21 | GSE190655 | GEO

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia [K562_RNA-seq]

2022-06-21 | GSE190653 | GEO

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia [ChIP-seq]

2022-06-21 | GSE190652 | GEO

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia (ChIP-Seq)

2022-06-21 | GSE202207 | GEO