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Epigenome screen suggests DNA methylation may affect beef tenderness through signal transduction in Bos indicus

ABSTRACT: Epigenome screen suggests DNA methylation may affect beef tenderness through signal transduction in Bos indicus

PROVIDER: PRJNA789197 | ENA |

REPOSITORIES: ENA

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Epigenome screen suggests DNA methylation may affect beef tenderness through signal transduction in Bos indicus

Project description:Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the genetic and epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs and deliver a better product quality to consumers. However, little is known about epigenetic effects in the muscle of Bos taurus and their implications in tenderness, and no studies have been conducted in Bos indicus. Therefore, we analyzed Reduced Representation Bisulfite Sequencing (RRBS) to search for differences in the methylation profile of Bos indicus skeletal muscle with extreme values for beef tenderness (tender = 6 animals, tough = 6 animals).

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Analysis of DNA Methylome Profiles in Cattle with Divergent Tenderness

Project description:Beef constitutes one of the main food sources worldwide due to its high quality protein and other nutrients. Beef tenderness is one of the most important factors influencing the edible quality. To date, a large number of molecular studies have focused on the exploration of mechanisms to form beef tenderness. DNA methylation is the most studied epigenetic modification and research revealed that DNA methylation plays important roles in diverse process. However, the genome-wide DNA methylation regulation on beef quality and tenderness remains unknown. In this study, we reported the DNA methylome profiling related to divergent tenderness of beef. We found that more reads are harbored in the intron, exon and repeat elements of genes of beef. We identified the DMRs between tender and tough beef. And results showed that DNA methylation levels in different part of genome or divergent tenderness are significantly differed. Then we annotated the DMRs and identified the top pathways DMRs are involved in. Meanwhile, we also explored the relationship between DNA methylation and gene expression. This study describes the detail DNA methylome profiling related with beef quality and may provide new strategies for exploring the mechanism of beef quality.

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