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Liver colonisation by colorectal cancer metastases requires YAP-controlled plasticity at the micrometastatic stage

ABSTRACT: Liver colonisation by colorectal cancer metastases requires YAP-controlled plasticity at the micrometastatic stage

PROVIDER: PRJNA795485 | ENA |

REPOSITORIES: ENA

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Liver colonisation by colorectal cancer metastases requires YAP-controlled plasticity at the micrometastatic stage

Project description:Human engineered CRC organoids were equipped with the intestinal stem cell reporter STAR reflecting transcriptional activity of ASCL2. Successfully growing organoids display heterogeneous STAR expression and grow into big structures, while growth-compromised organoids stay small and are either entirely STAR-pos or STAR-neg.

2022-02-23 | GSE193248 | GEO

Tumor metastasis to lymph node requires YAP-dependent metabolic adaptation

Project description:In cancer patients, metastasis of tumors to sentinel lymph nodes (LN) predicts disease progression and often guides treatment decisions. The mechanisms underlying tumor LN metastasis are poorly understood. Using comparative transcriptomics and metabolomics analyses of primary and LN metastatic tumors in mice, we found that LN metastasis requires that tumor cells undergo a metabolic shift toward fatty acid oxidation (FAO). Transcriptional co-activator yes-associated protein (YAP) is selectively activated in LN metastatic tumors, leading to upregulation of genes in the FAO signaling pathway. Pharmacological inhibition of FAO or genetic ablation of YAP suppressed LN metastasis in mice. Several bioactive bile acids were highly accumulated in the LN metastatic tumor. Inhibition of FAO or YAP may merit exploration as therapeutic strategies for mitigating tumor LN metastasis.

2019-02-09 | E-MTAB-7621 | biostudies-arrayexpress

Tumor metastasis to lymph node requires YAP-dependent metabolic adaptation

Project description:Tumor metastasis to lymph node requires YAP-dependent metabolic adaptation

| PRJEB30960 | ENA

A single-cell RNA-sequencing time course of liver colonisation by colorectal cancer metastases

Project description:A single-cell RNA-sequencing time course of liver colonisation by colorectal cancer metastases

| PRJNA785488 | ENA

RNAseq analysis of osteosarcoma cell line with overexpression of YAP-S94A and YAP-S127A

Project description:The molecular mechanisms by which YAP regulates metastases development were studied using overexpression of mutated forms of YAP able or not to interact with TEAD. Molecular signatures were identified using RNA-sequencing analysis and genes set enrichment.

2021-09-16 | GSE184003 | GEO

Neisseria lactamica Colonisation

Project description:Neisseria lactamica Colonisation

| PRJEB2229 | ENA

Cooperation of MYC and b-catenin in liver tumorigenesis requires Yap/Taz

Project description:Cooperation of MYC and b-catenin in liver tumorigenesis requires Yap/Taz

| PRJNA575356 | ENA

Colonisation of Probiotic in Neoplasia.

Project description:Interventions: The probiotic is Escherichia coli Nissle 1917 (EcN), supplied as Mutaflor, Ardeypharm. Each tablet contains at least 5x108 colony forming units (CFU) EcN. Participants will take either 2 tablets of probiotic or placebo (sugar pill) per day for 14 to 28 days, prior to surgery or colonoscopy. Previous studies have administered probiotic for 28 days. This has been shown to be a safe human dose in earlier phase I trials that unfortunately did not measure colonisation as an end-point. The duration of intervention will depend upon the time participants are consented before their procedure (at least 14 days). Adherence of the intervention will be monitored by probiotic tablet return. Mutaflor and placebo tablets are provided for free from Ardeypharm. Primary outcome(s): Neoplastic colonisation as assessed by DNA sequencing of surplus pathology tissue.[5 years post-enrolment.] Study Design: Purpose: Treatment; Allocation: Randomised controlled trial; Masking: Blinded (masking used);Assignment: Parallel;Type of endpoint: Bio-availability

| 2468660 | ecrin-mdr-crc

Barley root gene expression during colonisation by Piriformospora indica

Project description:The fungal mutualist Piriformospora indica is colonising barley roots thereby mediating various beneficial effects to its host. The interaction is characterised by an initial biotrophic interaction stage which is followed by a cell death-dependent colonisation phase. We used microarrays to identify the global programme of gene expression during the colonisation process of barley roots by P. indica and to obtain informations into plant defense and metabolic reprogramming.

2009-04-29 | GSE13756 | GEO

Discovery of immediate YAP target genes with inducible form of YAP

Project description:Microarray analyses with cells/tissues overexpressing YAP have revealed many transcription targets of YAP (Dong et al, 2007; Zhao et al, 2008). However, as YAP induces transformation of non-cancerous cells, we thought many of known targets of YAP may be indirect consequence of transforming property of YAP. To identify the immediate transcription targets for YAP, we utilized immortalized mammary epithelial MCF-10A cells expressing a tamoxifen inducible, hyperactive (S127/381A) YAP mutant (MCF-10A ERT2-YAP 2SA). MCF-10A ERT2 and MCF-10A ERT2-YAP 2SA are generated. Each cell line was treated with 0.1% of ethanol (solvent) or 1uM of 4-hydroxytamoxifen for 2 or 6 hours. This makes 6 samples per set. The experiments were done in duplicate. The expression data from MCF-10A ERT2 and MCF-10A ERT2-YAP 2SA before tamoxifen treatment can serve as control.

2015-11-23 | E-GEOD-60579 | biostudies-arrayexpress

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