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Single-cell RNA and TCR sequencing of TRM and ReCirulating CD8+ T cells sorted from 4 HGSOC tumors

ABSTRACT: single-cell RNA and TCR sequencing of TRM and ReCirulating CD8+ T cells sorted from 4 HGSOC tumors

PROVIDER: PRJNA795984 | ENA |

REPOSITORIES: ENA

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single-cell RNA and TCR sequencing of TRM CD8+ T cells sorted from 8 HGSOC tumors

Project description:Purpose: Characterization of the gene expression profile and TCR profile of CD8+ TILs (TRM and re-circulating) from HGSOC to understand the immunogenicity of ovarian cancer

2022-03-07 | GSE194105 | GEO

single-cell RNA and TCR sequencing of TRM and ReCirulating CD8+ T cells sorted from 4 HGSOC tumors

Project description:Purpose: Characterization of the gene expression profile and TCR profile of CD8+ TILs (TRM and re-circulating) from HGSOC to understand the immunogenicity of ovarian cancer

2022-03-07 | GSE193371 | GEO

Bulk RNA sequencing of TRM and ReCirculating CD8+ T cells from 7 HGSOC tumors

Project description:Purpose: Characterization of the gene expression profile of CD8+ TILs (TRM vs. re-circulating) from 7 HGSOC

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single-cell RNA and TCR sequencing of TRM CD8+ T cells sorted from 8 HGSOC tumors

Project description:single-cell RNA and TCR sequencing of TRM CD8+ T cells sorted from 8 HGSOC tumors

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Single-cell RNA/ATAC multiomic analysis of TRM and ReCirulating CD8+ T cells from HGSOC tumors

Project description:Single-cell RNA/ATAC multiomic analysis of TRM and ReCirulating CD8+ T cells from HGSOC tumors

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Single-cell RNA/ATAC multiomic analysis of TRM and ReCirulating CD8+ T cells from HGSOC tumors

Project description:Purpose: Evaluation of the BCR profile of HGSOC associated/infiltrated B cells

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Single cell analysis reveals multiple subsets of CD8+ TRM and non-TRM cells with a type 17 signature in the inflamed psoriatic arthritis joint

Project description:CD69+CD103+ tissue-resident memory T-cells (TRM) are increasingly recognised as important drivers of inflammation. To decipher their potential role in inflammatory arthritis, we applied single cell, high-dimensional profiling (CyTOF and scRNAseq) to T-cells isolated from the joint of patients with psoriatic arthritis (PsA) or rheumatoid arthritis (RA). We identified three broad groups of synovial CD8+ TRM cells: cytotoxic and Treg-like TRM cells were present in the inflamed joints of patients with both PsA and RA, while CD161+CXCR6+ type 17-like TRM cells with a pro-inflammatory cytokine profile (IL-17A+TNFa+IFNg+) and a distinct transcriptomic signature and a polyclonal, but distinct TCR repertoire, were specifically enriched in the inflamed joints of patients with PsA. Type 17-like cells were also enriched in non-TRM CD8+ T-cells in PsA compared to RA. These findings add substantively to the accumulating evidence that the immunopathology of PsA and RA is different, with a particular role for type 17 cells in PsA.

2023-05-17 | GSE216914 | GEO

Bulk RNA-seq of tumor antigen specific CD8 Tissue Resident Memory (Trm) Cells

Project description:Purpose: To characterize the tumor-specific TRM cells in LNs, skin, lung and liver in mice with melanoma-associated vitiligo (MAV). Bulk RNA-seq was performed to identify populations of CD8 T cells with TRM transcriptional characteristics. Methods: CD8+THy1.1+ T cells were sorted from DLN, skin lung and liver of MAV mice and bulk RNA-sequenced Results: Heterogenouse CD8 memory populations with both circulatating and resident phenotypes were identified. Conclusions: Tumor-specific CD8 T cells form TRM responses in tumor-draining LNs.

2021-07-04 | GSE169237 | GEO

Genome-wide transcriptional analysis of CD8+ brain TRM during CNS autoimmunity

Project description:CD8+ TRM are described in autoimmune and chronic inflammatory diseases. However, we still lack knowledge about mechanisms regulating TRM reactivation, in particular in autoimmune diseases. Here, we investigated in a model of TRM-driven central nervous system autoimmunity the transcriptional landscape of self-reactive brain TRM and the requirement of these cells for CD4+ T cell help.

2023-01-25 | GSE189580 | GEO

Characterization of resident CD8+ Trm cell populations using whole-genome biomarker analysis

Project description:This study seeks a better understanding of the functional differences between naturally acquired murine CD8+ T resident memory (Trm) cells of three distinct mucosal environments; the small intestine, the lung and the liver. CD8+ Trm cells of healthy young adult mice were retrieved from their respective organ environments by automated organ disintegration and MACS sorting, and compared with each other by whole genome gene expression profiling. Peripheral blood derived circulating CD8+ Tem cells were also analyzed, serving as nonresident peripheral memory T cell controls, in an attempt to identify common characteristics of resident mucosal CD8+ Trm subsets, as well.

2019-01-04 | GSE65044 | GEO

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