Project description:Targeted bisulphite pyrosequencing of the major histocompatibility complex (MHC) region was performed using CATCH-Seq kits on whole blood DNA isolated from healthy controls and patients with rheumatoid arthritis. Data analysis showed 74 unique and differentially methylated loci (DMLs) in the MHC region of RA patients compared to healthy controls. Further, differentially methylated CpGs in C6orf10 gene were negatively associated with preclinical RA risk factors.
Project description:The purpose of the experiment was to compare placental transcriptome of rhesus macaque at approximately 80% completed gestation to human placental transcriptomes.
