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Expression data from murine MPS I fibroblasts under flavonoids treatment

ABSTRACT: Expression data from murine MPS I fibroblasts under flavonoids treatment

PROVIDER: PRJNA796690 | ENA |

REPOSITORIES: ENA

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Expression data from murine MPS I fibroblasts under flavonoids treatment

Project description:Flavonoids are biological compounds with high potency to modulate molecular processes. The study was designed to estimate genistein, kaempferoland their mixture impact on global gene expression, with special focus on key processes in MPS pathogenesis. We used microarrays to detail the global program of gene expression underlying flavonoid treatment and identified distinct classes of regulated genes during this process.

2022-01-15 | GSE193583 | GEO

Microarray analysis of Normal and MPS VII mouse aorta

Project description:Mucopolysaccharidosis VII (MPS VII) is due to mutations within the gene encoding the lysosomal enzyme beta-glucuronidase, and results in the accumulation of glycosaminoglycans. MPS VII causes aortic dilatation and elastin fragmentation. In this study we performed microarray analysis of ascending aortas from normal and MPS VII mice, trying to find out possible genes responsible for the phenotype observed. In addition, during our breeding strategy, we noticed that some MPS VII mice had less dilated aortas, and we proposed that an yet-unidentified gene could be responsible for the difference observed. We therefore included in the analysis two MPS VII mice with aortas that were not dilated. Total RNA extracted from ascending aortas from 3 Normal mice, 3 MPS VII mice with dilated aortas and 2 MPS VII mice with aortas that were not dilated.

2011-10-09 | E-GEOD-30657 | biostudies-arrayexpress

Effect of RT-MPs treatment on gene expression of stem-like Lewis cells

Project description:To further elucidate the mechanism underlying the RT-MPs killing effect on SLTCs, we performed RNA-seq on stem-like Lewis cells and RT-MP-treated stem-like Lewis cells We then performed gene expression profiling analysis using data obtained from RNA-seq of stem-like Lewis cells untreated or treated with RT-MPs for 48 h

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Expression data of Normal versus Mutant MPS VII C3H mouse

Project description:We used microarray to detect pathway differences in the various brain regions in a monogenic in mucopolysaccharidosis type VII ( MPS VII ), a mouse model of a lysosomal storage disease A number of changes revealed unexpected system and process alterations, such as upregulation of the immune system with few inflammatory changes (a significant difference from the closely related MPS IIIb model), down-regulation of major oligodendrocyte genes even though white matter changes are not a feature histopathologically, and a plethora of developmental gene changes. 94 samples, no replicates, made up of half normals and half MPS mutant mice for the MPS VII mutation backcrossed on a C3h-heouj background

2012-12-01 | E-GEOD-34071 | biostudies-arrayexpress

Smilax glabra flavonoids treatment of 3T3-L1 adipocytes

Project description:Smilax glabra Roxb, a traditional Chinese herb, has been widely used for folk medicine. Previous studies have found that it has various pharmacological activities, such as cytotoxic, anti-inflammation, anti-oxidant, hepatoprotective, and cardiovascular system protective activities. However, its roles in adipogenesis are poorly understood. We hypothesized that Smilax glabra Roxb and its main component may play important roles in regulating adipocyte diffrentiation and function. To test this hypothesis, we performed RNA-Seq on 3T3-L1 adipocytes treated with and without pure total flavonoids from Smilax glabra Roxb.

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The transcriptome of murine dermal fibroblasts

Project description:The transcriptome of murine dermal fibroblasts

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Microarray analysis of Normal and MPS VII mouse aorta

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Smilax glabra flavonoids treatment of 3T3-L1 adipocytes

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Transcriptomal profiling of liver microphysiological system (MPS) co-culture NASH model under varying culture conditions

Project description:Purpose: Liver MPS NASH model was cultured in the presence or absence of six independent cues to identify the culture conditions that produce a model of NAFLD/NASH that most closely represents the human disease state.

2021-09-15 | GSE168285 | GEO

Microarray experiment of murine macrophages co-cultured with neural stem cells in the presences of LPS

Project description:This experiment aimed at characterising the modulatory role of murine induced Neural Stem Cells (iNSCs) and Neural Stem Cells (NSCs) on macrophages (MPs) exposed to LPS in vitro. NaÃ¯ve MPs were polarized into an M1-like phenotype with LPS, and then co-cultured with 1:1 ratios of iNSCs in a trans-well system that avoids cell-to-cell contacts. NaÃ¯ve MPs, LPS-stimulated MPs and LPS-stimulated MPs co-cultured with NSCs were used as controls.

2018-01-01 | E-MTAB-5579 | biostudies-arrayexpress

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