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RDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - RNAseq

ABSTRACT: rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - RNAseq

PROVIDER: PRJNA796837 | ENA |

REPOSITORIES: ENA

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rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - ATACseq

Project description:In this study we perform ATAC-seq of budding yeast strains with variable copy number of the rRNA genes (rDNA CN). We aim to better understand the relationship between DNA accessibility and replicative lifespan in strains with variable rDNA CN.

2022-04-05 | GSE193598 | GEO

rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast.

Project description:rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast.

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rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - ATACseq

Project description:rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - ATACseq

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rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast - RNAseq

Project description:In this study we perform RNA-seq of budding yeast strains with variable copy number of the rRNA genes (rDNA CN) to assess the relationship between rDNA CN and gene expression. RNA-seq was performed on samples both with and without polyA selection (for all transcripts and for rRNA transcripts, respectively).

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rDNA Array Length is a Major Determinant of Replicative Lifespan in Budding Yeast.

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:The involvement of protein chaperones in aging is intriguing and their potential contribution has, so far, been attributed solely to their central role in proteostasis. Here we show that four protein chaperones from different cellular compartments extend replicative lifespan (RLS) in budding yeast by a common mechanism akin to caloric restriction. The RLS extension relies on the increased direct activation of Snf1 kinase by Hsp90, thereby bypassing the signal on the environmental glucose level. The chaperone-related RLS extension is accompanied by the uncoupling of the respiratory chain. A genomic approach confirmed the repression of glycolysis and cytoplasmic translation, and contrary, activation of gluconeogenesis and fatty acid oxidation. Our results set a novel paradigm for the role of protein chaperones: by modulation of the chaperone expression level one can affect metabolic features such as glucose sensing, fatty acid consumption, respiration rate, and, consequently, modify lifespan. We expect the described mechanism to open new avenues for research in aging and age-related diseases.

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Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae

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