Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Long-distance association of topological boundaries through nuclear condensates (Hi-C)

ABSTRACT: Long-distance association of topological boundaries through nuclear condensates (Hi-C)

PROVIDER: PRJNA801256 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Long-distance association of topological boundaries through nuclear condensates (Hi-C)

Project description:Chromatin is partitioned into distinct topological domains in an activity-dependent manner, with topological boundaries limiting the interaction between adjacent domains. Recent studies support the concept that several well-established nuclear compartments are assembled as ribonucleoprotein condensates. Here we ask whether the physical processes driving the assembly of the nuclear condensates play any role in three-dimensional chromatin architecture. We report that the insulation of approximately 20% of topological boundaries in human embryonic stem cells is substantially weakened following brief treatment with 1,6-hexanediol, a chemical known to disrupt several nuclear condensates. The disrupted boundaries are characterized by a high level of transcription, striking spatial clustering, and the augmented presence of transcription units widely expressed in diverse cell types. These topological boundary regions tend to be spatially associated, even inter-chromosomally, and segregate with nuclear speckles. These observations reveal a previously unappreciated mode of genome organization mediated by conserved boundary elements harboring widely-expressed transcription units and associated transcriptional condensates.

2022-06-15 | GSE195565 | GEO

Long-distance association of topological boundaries through nuclear condensates

Project description:Long-distance association of topological boundaries through nuclear condensates

| PRJNA801249 | ENA

Long-distance association of topological boundaries through nuclear condensates (GRO-Seq)

2022-06-15 | GSE195562 | GEO

Long-distance association of topological boundaries through nuclear condensates (PRO-Seq)

2022-06-15 | GSE195563 | GEO

Long-distance association of topological boundaries through nuclear condensates (ChIP-Seq)

2022-06-15 | GSE195561 | GEO

Long-distance association of topological boundaries through nuclear condensates (GRO-Seq)

Project description:Long-distance association of topological boundaries through nuclear condensates (GRO-Seq)

| PRJNA801254 | ENA

Long-distance association of topological boundaries through nuclear condensates (ChIP-Seq)

Project description:Long-distance association of topological boundaries through nuclear condensates (ChIP-Seq)

| PRJNA801255 | ENA

Long-distance association of topological boundaries through nuclear condensates (PRO-Seq)

Project description:Long-distance association of topological boundaries through nuclear condensates (PRO-Seq)

| PRJNA801257 | ENA

Long-distance association of topological boundaries through nuclear condensates

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-13 | GSE195566 | GEO

Hi-C of early Drosophila melanogaster embryos

Project description:We use deep-sequencing of Hi-C libraries to identify topological boundaries at high resolution and show that boundaries, insulators, and polytene interbands converge on the same short genomic elements.

2017-11-20 | GSE100370 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data