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Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

ABSTRACT: Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

PROVIDER: PRJNA803502 | ENA |

REPOSITORIES: ENA

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Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

Project description:In this study, we determined the expression of V. cholerae strain A1552 and its SNP45-converted derivative as well as the expression of strain ATCC25872 and its SNP45-converted derivative.

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Project description:We report the transcriptome of Burkholderia pseudomallei type VI secretion regulator TctR mutant grown in rich media compared to wild type. The RNA-seq studies confirmed the role of TctR as a negative regulator of T6SS-2, a positive regulator of T6SS-6 and suggest a potential role in regulation of the T6SS-3 and T6SS-4 gene clusters.

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Next Generation Sequencing to analyse regulators of constitutive VWF secretion

Project description:Constitutive VWF secretion can be increased by a range of factors; changes in VWF expression, levels of TNF-alpha or other environmental cues. An RNAseq analysis revealed that expression of RGS4 (Regulator of G protein signalling 4) was reduced in endothelial cells (HUVECs) grown under these conditions. si-RGS4 treatment of HUVECs increased constitutive basolateral secretion of VWF, probably by affecting the anterograde secretory pathway. In a simple model of endothelial damage we show that RGS4-silenced cells increased platelet recruitment onto the subendothelial matrix under flow. These results show that changes in RGS4 expression alter levels of subendothelial VWF, affecting platelet recruitment. This introduces a novel control over VWF function.

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Bioinformatic analysis of the Campylobacter jejuni Type VI secretion system

Project description:Bioinformatic analysis of the Campylobacter jejuni Type VI secretion system

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Next Generation Sequencing to analyse regulators of constitutive VWF secretion

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Expression data from D. melanogaster whole guts or intestinal progenitor cells isolated from flies mock infected or infected with wild type Vibrio cholerae (C6706) or type VI secretion system deficient Vibrio cholerae (C6706ΔvasK)

Project description:We used RNA-seq to determine transcriptional profiles of whole guts or IPCs isolated from guts infected with wild type or type VI secretion system deficient Vibrio cholerae. We found significant differences between guts and progenitor cells infected wild type or type VI secretion system deficient Vibrio cholerae.

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anti-fungal effectors delivered by the Type VI secretion system - a proteomic analysis

Project description:Targeting a new kingdom: anti-fungal effectors delivered by the Type VI secretion system

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Prevalence of Type VI Secretion System in Spanish Campylobacter jejuni Isolates

Project description:Prevalence of Type VI Secretion System in Spanish Campylobacter jejuni Isolates

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In vivo actin cross-linking induced by type VI secretion system is associated with intestinal inflammation

Project description:To determine whether the Vibrio cholerae type VI secretion system (T6SS) is functional during animal infection, derivatives of V52 were used to infect infant mice. In this infection model, a diarrheal response occurred and effector translocation could be detected. These host responses were dependent on a functional T6SS and on the actin cross-linking effector domain of VgrG-1. Gene expression and histological studies showed innate immune activation and immune cell infiltration in the intestinal lumen.

2010-01-20 | GSE19946 | GEO

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