Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

ABSTRACT: Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

PROVIDER: PRJNA813852 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

MethylC-Seq: Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Project description:MethylC-Seq: Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

| PRJNA816200 | ENA

MethylC-Seq: Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Project description:The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.

2022-03-14 | GSE198638 | GEO