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A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [mRNA-seq]

ABSTRACT: A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [mRNA-seq]

PROVIDER: PRJNA813864 | ENA |

REPOSITORIES: ENA

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A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers

Project description:A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers

| PRJNA813858 | ENA

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [miRNA-seq]

Project description:A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [miRNA-seq]

| PRJNA813863 | ENA

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [RNA-seq and smallRNA-seq]

Project description:A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [RNA-seq and smallRNA-seq]

| PRJNA819373 | ENA

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [miRNA-seq]

Project description:Cancer cells are featured with uncontrollable activation of cell cycle and proliferation,and microRNA deficiency drives tumorigenesis. The RNA-dependent RNA polymerase (RDR) is essential for small RNA-mediated immune response in plants, but absent in vertebrates with adaptive immunity. Here we show that ectopic expression of plant RDR1 can generally inhibit the proliferation of different cancer cells. Interestingly, we find that abnormal AGO2-free microRNA isoforms with 1-nucleotide shortening at the 3’ end are widely accumulated in many tumors. RDR1 with nucleotidyltransferase activity can recognize and modify these problematic microRNAs with mononucleotides to restore their AGO2 loading efficiency, which eventually rescues microRNA deficiency and elevates microRNA expression to target cell cycle in cancer specifically. The wide antitumor effects of RDR1 can be visualized in multiple xenograft tumor models in vivo, which can be realized by adeno-associated virus-mediated delivery. Altogether, we develop a broad microRNA-mediated antitumor stratagem using the plant immune protein RDR1.

2022-03-08 | GSE198146 | GEO

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [mRNA-seq]

2022-03-08 | GSE198145 | GEO

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers [RNA-seq and smallRNA-seq]

2022-03-24 | GSE199309 | GEO

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency in cancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-08 | GSE198147 | GEO

Roadmap Epigenomics Program - Broad

Project description:Roadmap Epigenomics Program - Broad

| PRJNA233641 | ENA

Nocardioidaceae bacterium Broad-1

Project description:Nocardioidaceae bacterium Broad-1 overview

| PRJNA48541 | ENA

Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

Project description:The concept of targeting cholesterol metabolism to treat cancer has been widely tested in clinics but the benefits are modest, calling for a complete understanding of cholesterol metabolism of intratumoral cells. Low cholesterol levels inhibit T-cell proliferation and cause autophagy mediated apoptosis, particularly for cytotoxic T cells. In the tumor microenvironment, oxysterols mediate reciprocal alterations of the LXR and SREBP2 pathways to cause cholesterol deficiency of T cells, subsequently leading to aberrant metabolic and signaling pathways that drive T cell exhaustion/dysfunction. LXR depletion in CAR-T cells led to improved antitumor function against solid tumor.

2023-04-13 | GSE229611 | GEO

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