Genomics

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Sustainedcorrection of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mousemodel of Fragile X Syndrome.


ABSTRACT: Sustainedcorrection of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mousemodel of Fragile X Syndrome.

PROVIDER: PRJNA814887 | ENA |

REPOSITORIES: ENA

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Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome.

Javadi Sahar S   Li Yue Y   Sheng Jie J   Zhao Lucy L   Fu Yao Y   Wang Daifeng D   Zhao Xinyu X  

BMC medicine 20220513 1


<h4>Background</h4>Fragile X syndrome (FXS), the most prevalent inherited intellectual disability and one of the most common monogenic forms of autism, is caused by a loss of fragile X messenger ribonucleoprotein 1 (FMR1). We have previously shown that FMR1 represses the levels and activities of ubiquitin ligase MDM2 in young adult FMR1-deficient mice, and treatment by a MDM2 inhibitor Nutlin-3 rescues both hippocampal neurogenic and cognitive deficits in FMR1-deficient mice when analyzed shortl  ...[more]

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