Project description:Lymphatic filarial nematodes maintain a mutualistic association with the intracellular bacterium Wolbachia. Wolbachia populations expand following infection of the mammalian host, to support larval growth and development. Utilizing transcriptomic data from Brugia malayi over the first two weeks post-infection, we present an analysis of the biochemical pathways that are involved in Wolbachia population growth and regulation in support of larval development. In Wolbachia, we observe coordinated regulation of carbon metabolism with an alternating pattern of glycolysis and TCA cycle pathways reminiscent of the ‘Warburg effect’. Wolbachia's purine, pyrimidine and haem biosynthesis and Type IV secretion pathways are also upregulated and correlate with the upregulation of the nematode’s DNA replication pathway. In the nematode we observe up-regulation of the autophagy pathway, a key regulator of Wolbachia populations. These findings support a key role for nucleotide and haem provisioning from Wolbachia in support of the larval growth and development of its nematode host.

2021-06-30 | GSE132848 | GEO

Tissue-Specific Transcriptomics and Proteomics of a Filarial Nematode and its Wolbachia Endosymbiont

Project description:We sequenced total RNA from Dirofilaria immitis in order to generate the first tissue-specific gene expression profile of a filarial nematode and its Wolbachia endosymbiont.

2016-06-01 | GSE67894 | GEO

Wolbachia endosymbiont of Onchocerca volvulus strain:wOV_K5 | isolate:wOV_K5

Project description:Wolbachia sp. wOV_K5 Endosymbionts of Onchocerca volvulus

| PRJNA282510 | ENA

Wolbachia endosymbiont of Onchocerca volvulus strain:wOV_K2 | isolate:wOV_K2

Project description:Wolbachia sp. wOV_K2 Endosymbionts of Onchocerca volvulus

| PRJNA282509 | ENA

Onchocerca ochengi

Project description:Onchocerca ochengi overview

| PRJNA208968 | ENA

Genomic diversity in Onchocerca volvulus and its Wolbachia endosymbiont.

Project description: Not available

| S-EPMC5512550 | biostudies-literature

Tissue-Specific Transcriptomics and Proteomics of a Filarial Nematode and its Wolbachia Endosymbiont

Project description:We sequenced total RNA from Dirofilaria immitis in order to generate the first tissue-specific gene expression profile of a filarial nematode and its Wolbachia endosymbiont. Examination of transcript levels in 7 different Dirofilaria immitis tissues, in duplicate, using Illumina GAIIx.

2016-06-01 | E-GEOD-67894 | biostudies-arrayexpress

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