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Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

ABSTRACT: Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

PROVIDER: PRJNA823290 | ENA |

REPOSITORIES: ENA

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Blood transcriptome following intravenous BCG vaccination in rhesus macaques

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Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

Project description:We used longitudinal scRNA-seq, PET-CT, and bacterial burden assays to understand the cellular features underlying granuloma timing and burden/resolution.

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Correlates of Durability and Boosting Following Ad26.COV2.S Immunization in Rhesus Macaques

Project description:Ad26.COV2.S is a single-shot vaccine with clinical efficacy against symptomatic COVID-19. In this study, we report the correlates of durability of humoral and cellular immune responses in 20 rhesus macaques immunized with single-shot Ad26.COV2.S and the immunogenicity of a booster shot at 8-10 months following the initial immunization. Innate immune responses, memory B cell responses, and bone marrow plasma cell responses correlated with durable antibody responses following initial vaccination. Following Ad26.COV2.S boost immunization, binding and neutralizing antibody responses increased 31-69 fold and 23-43 fold, respectively, compared with pre-boost levels against multiple SARS-CoV-2 variants, including the delta variant. Antigen-specific B cell and T cell responses also increased. Humoral and cellular immune responses were largely comparable for ancestral, alpha, beta, gamma, delta, and kappa SARS-CoV-2 variants following the boost immunization. Boosting with a modified Ad26.COV2.S.351 vaccine expressing the SARS-CoV-2 beta Spike led to largely comparable responses. These data demonstrate that a late boost with Ad26.COV2.S in rhesus macaques resulted in a dramatic increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants.

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Gene expression profiling of granuloma T cells in M. tuberculosis infected rhesus macaques reveals a critical role for CD30 [Mus musculus]

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Gene expression profiling of granuloma T cells in M. tuberculosis infected rhesus macaques reveals a critical role for CD30 [Macaca mulatta]

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Molecular and Cellular Correlates of Nerve Repair in Humans

Project description:Molecular and Cellular Correlates of Nerve Repair in Humans

| PRJNA526948 | ENA

Molecular and Cellular Correlates of Nerve Repair in Humans

Project description:Molecular and Cellular Correlates of Nerve Repair in Humans

| PRJNA526949 | ENA