Project description:The leaf transcriptome of the nickel hyperaccumulator Phyllanthus luciliae (Phyllanthaceae) endemic from New Caledonia was compared to the related non-accumulator Phyllanthus conjugatus var. ducosensis, living respectively on ultramafic and sedimentary soil, to identity differentially expressed genes potentially involved in Ni hyperaccumulation.
Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
