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DPP-4 inhibitor sitagliptin improves vascular endothelial function by modulating lncRNA and mRNA expression profiles in obese mouse aortae.

ABSTRACT: DPP-4 inhibitor sitagliptin improves vascular endothelial function by modulating lncRNA and mRNA expression profiles in obese mouse aortae.

PROVIDER: PRJNA826865 | ENA |

REPOSITORIES: ENA

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DPP-4 inhibitor sitagliptin improves vascular endothelial function by modulating lncRNA and mRNA expression profiles in obese mouse aortae.

Project description:To investigated the therapeutic mechanism underlying the sitagliptin improves vascular endothelial function in obesity, we performed bioinformatics analyses on the expression profiles of long noncoding RNAs (lncRNAs) and message RNAs (mRNAs) in the aortae from obese mice with or without sitagliptin treatment.

2022-04-19 | GSE200814 | GEO

DPP-4 inhibitor MK-626 improves vascular endothelial function by modulating lncRNA and mRNA expression profiles in Ang II-induced hypertensive mouse aortae.

Project description:To investigated the therapeutic mechanism underlying the MK-626 improves vascular endothelial functionin hypertension, we performed bioinformatics analyses on the expression profiles of long noncoding RNAs (lncRNAs) and message RNAs (mRNAs) and in the aortae from Ang Ⅱ-induced hypertensive mice with or without MK-626 treatment.

2021-08-11 | GSE165561 | GEO

DPP-4 inhibitor MK-626 improves vascular endothelial function by modulating lncRNA and mRNA expression profiles in Ang II-induced hypertensive mouse aortae.

Project description:DPP-4 inhibitor MK-626 improves vascular endothelial function by modulating lncRNA and mRNA expression profiles in Ang II-induced hypertensive mouse aortae.

| PRJNA694984 | ENA

Identification of Dpp target genes during the early embryo development

Project description:The dorsal patterning in Drosophila is controlled by an extracellular gradient of the morphogens Decapentlaplegic/Screw (Dpp/Scrw), which are members of BMP/TGF-β family. Dpp/Scrw signal is transduced to the nucleus by the transcription factors, Mad/Medea. The transcriptional effectors exert their regulation in a graded-manner eliciting at least three threshold responses: high, intermediate and low. However, the mechanism underlying differential response to Dpp is poorly understood, due in part to the insufficient number of well-studied target genes. Gene expression changes were analysed in ectopic overexpressing Dpp mutant embryos to identify new target genes of Dpp/Mad pathway.

2016-02-24 | GSE78226 | GEO

Diabetes Prevention Program (DPP)

Project description:Diabetes Prevention Program (DPP)

| PRJNA227394 | ENA

Aortae of 32 weeks old apoE mice

Project description:Aortae of 32 weeks old apoE mice versus wild type mice on a C57BL/6J Background. Keywords = mouse aorta microarray Keywords: other

2005-05-04 | GSE2372 | GEO

Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis

Project description:In animals, the brain regulates feeding behavior in response to local energy demands of peripheral tissues, which secrete orexigenic and anorexigenic hormones. Although skeletal muscle is a key peripheral tissue, it remains unknown whether muscle-secreted hormones regulate feeding. In Drosophila , we find that decapentaplegic (dpp), the homolog of human bone morphogenetic proteins BMP2 and BMP4, is a muscle-secreted factor (a myokine) that is induced by nutrient sensing and that circulates and signals to the brain. Muscle-restricted dpp RNAi promotes foraging and feeding initiation whereas dpp overexpression reduces it. This regulation of feeding by muscle-derived Dpp stems from modulation of brain tyrosine hydroxylase (TH) expression and dopamine biosynthesis. Consistently, Dpp receptor signaling in dopaminergic neurons regulates TH expression and feeding initiation via the downstream transcriptional repressor Schnurri. Moreover, pharmacologic modulation of TH activity rescues the changes in feeding initiation due to modulation of dpp expression in muscle. These findings indicate that muscle-to-brain endocrine signaling mediated by the myokine Dpp regulates feeding behavior.

2019-11-15 | GSE140391 | GEO

Berberine ameliorates vascular dysfunction by a global modulation of mRNA and lncRNA expression profiles in hypertensive mouse aortae

Project description:To investigated the mechanism underlying the therapeutic effects of berberine in the vasculature in hypertension, we performed systematical analyses on the expression profiles of message RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in the aortae from Ang Ⅱ-induced hypertensive mice with or without berberine treatment.

2021-03-03 | GSE159725 | GEO

CTCF and Smad signaling proteins and response to DPP

Project description:ChIP-seq profiles for CTCF and TGF-beta signaling factors before and after treatment with DPP

2015-05-08 | GSE68654 | GEO

Identification of genes whose expression is affected by ptc + dpp double RNAi in spider embryos

Project description:In the spider Parasteatoda tepidariorum, Hedgehog (Hh) and Decapentaplegic (Dpp) signaling play key roles in the formation of the two major embryonic axes (Akiyama-Oda and Oda, 2010, Development 137, 1263-1273; Akiyama-Oda and Oda, 2006, Development 133, 2347-2357). Patched (Ptc), a receptor for Hh,functions as a negative regulator of Hh signaling. Double parental RNA interference (pRNAi) against spider homologs of ptc and dpp, Pt-ptc and Pt-dpp, respectively, results in severe defects in axis formation. In this microarray experiment, we attempted to identify candidate genes whose expressions are regulated by Hh and Dpp signaling during axis formation.

2019-03-15 | GSE112435 | GEO

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